The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis
Figure 3
The effect of sirtinol on cell cycle distribution of lung cancer cells. H1299 cells treated with indicated concentrations (from 5 to 50 μM) of sirtinol for 24 h, respectively. Cells were stained with PI and detected the cell cycle distribution by flow cytometry. (a) Flow cytometry profile represents PI staining in -axis and cell number in -axis. (b) The quantitative analysis of cell cycle distribution. Different letter notations indicate the statistical significance between drug treatment and vehicle (a versus b and a versus c indicate the and 0.001, resp.).
