The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis
Figure 4
Sirtinol induces apoptosis of H1299 cells. Cells were treated with indicated concentrations of sirtinol and stained with Annexin-V and PI at 24 h, respectively. (a) Flow cytometry profiling represents the results of Annexin-V-FITC staining. (b) The quantificative analysis of cell apoptosis. Different letter notations indicate the statistical significance between sirtinol treatment and vehicle (a versus b and a versus c indicate the and 0.001, resp.).
