The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/<i>β</i>-Catenin-Foxo3A Axis

<table>Modulation of protein levels in NSCLC H1299 cells after sirtinol treatment. H1299 cells treated with indicated concentrations (10, 20, and 50 <i>μ</i>M) of sirtinol for 24 h, respectively. The results of Western blot of Sirt1 nonhistone target protein, including FoxO3a, Akt phosphorylation, and <i>β</i>-catenin. <i>β</i>-Actin as an internal control.</table>

The Scientific World Journal

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Figure 5

Figure 5: The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/<i>β</i>-Catenin-Foxo3A Axis 

Figure 5 | The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis 