The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis
Figure 6
Possible model of sirtinol-induced antiproliferation and apoptosis in lung cancer cells. Sirtinol downregulates the activation of prosurvival Akt serine/threonine kinase and the protein level of β-catenin, a proliferation-associated transcription factor, insulting in the cell cycle G1-phase accumulation and the growth arrest. On the contrary, sirtinol treatment causes the upregulation of the proapoptotic transcription factor FoxO3a, a target of both Akt signaling and Sirt1. This may render H1299 cells more sensitive to apoptosis. Finally, sirtinol induces the apoptosis of lung cancer cells.
