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The Scientific World Journal
Volume 2014, Article ID 946265, 5 pages
Research Article

Detection of Impaired Cognitive Function in Rat with Hepatosteatosis Model and Improving Effect of GLP-1 Analogs (Exenatide) on Cognitive Function in Hepatosteatosis

1Department of Physiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
2Department of Internal Medicine, School of Medicine, Ege University, Izmir, Turkey
3Department of Geriatrics Medicine, Medical Faculty, Ege University, 5th Floor, Bornova, 35100 Izmir, Turkey
4Department of Histology and Embryology, School of Medicine, Ege University, Izmir, Turkey
5Department of Physiology, School of Medicine, Ege University, Izmir, Turkey

Received 20 September 2013; Accepted 22 January 2014; Published 11 March 2014

Academic Editors: P. Campiglia, G. Iaccarino, and N. Montuori

Copyright © 2014 Oytun Erbaş et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aims of the study were to evaluate (1) detection of cognitive function changing in rat with hepatosteatosis model and (2) evaluate the effect of GLP-1 analog (exenatide) on cognitive function in hepatosteatosis. In the study group, 30% fructose was given in nutrition water to perform hepatosteatosis for 8 weeks to 18 male rats. Six male rats were chosen as control group and had normal nutrition. Fructose nutrition group were stratified into 3 groups. In first group ( ), intracerebroventricular (ICV) infusion of exenatide ( ) was given. ICV infusion of NaCl ( ) was given to second group. And also, the third group had no treatment. And also, rats were evaluated for passive avoidance learning (PAL) and liver histopathology. Mean levels of latency time were statistically significantly decreased in rats with hepatosteatosis than those of normal rats ( ). However, mean level of latency time in rats with hepatosteatosis treated with ICV exenatide was statistically significantly increased than that of rats treated with ICV NaCl ( ). Memory performance falls off in rats with hepatosteatosis feeding on fructose (decreased latency time). However, GLP-1 ameliorates cognitive functions (increased latency time) in rats with hepatosteatosis and releated metabolic syndrome.