The Scientific World Journal

Novel Therapeutic Targets in Metabolic Disorders: From the Bench to the Bedside


Publishing date
13 Dec 2013
Status
Published
Submission deadline
04 Oct 2013

1Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy

2SDN Foundation Naples, Naples, Italy

3Department of Medicine and Surgery, University of Salerno, Salerno, Italy

4Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, 84084 Salerno, Italy

5Owensboro Cancer Research Program, University of Louisville, Owensboro, KY 42303, USA


Novel Therapeutic Targets in Metabolic Disorders: From the Bench to the Bedside

Description

The endocrine system coordinates many biological functions orchestrating multiple biochemical pathways. Hormones are often implicated in the pathogenesis of multifactorial diseases, either increasing susceptibility or conditioning prognosis, and the phenotype of endocrine-metabolic diseases derives from the interaction between hormonal, environmental, and genetic factors. Endocrine-metabolic diseases chronic course determines a substantial burden on health care systems.

The regulatory mechanisms of steroid hormone metabolism, gonadotropin release and action, insulin secretion and action, and adipose tissue metabolism are often investigated to address etiopathogenesis, prevention, and therapy and to improve the outcome. Indeed, the discovery of novel features of the disease mechanisms provides additional therapeutic targets and unveils diagnostic tools for early diagnosis. All approaches pose a range of issues to be addressed by further research. Hence, continuous efforts and increasing interest are directed to the study of the crosstalk between signaling pathways to discover novel diagnostic and therapeutic targets, in a synergic collaboration among different expertise (pharmaceutical chemistry, biology and biochemistry, and clinicians).

The advantage this approach poses rests in the opportunity to use available compounds in different clinical contexts, thus supporting the extension of their therapeutic indications. Interdisciplinary analysis improves the ability to bring basic research findings to the bedside, evaluate the efficacy of interventions across communities, and enable the assessment of the impact of translational medicine innovations on health policies.

We invite authors to contribute original as well as review articles. Potential topics include, but are not limited to:

  • Ubiquitary signal transduction molecules as key regulators of biological responses: calcium signaling cascades
  • Crosstalk in signal transduction pathways as a leading guide to identify therapeutic targets: new and old molecules for novel targets
  • Molecular tests for early diagnosis of metabolic disorders: towards a sophisticated management of complex diseases
  • Cardiovascular involvement in patients affected by metabolic disorders
  • Inflammatory signaling cascades in metabolic diseases

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/tswj/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/tswj/endocrinology/emeta/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 365974
  • - Editorial

Novel Therapeutic Targets in Metabolic Disorders: From the Bench to the Bedside

Maddalena Illario | Carolina Di Somma | ... | Nunzia Montuori
  • Special Issue
  • - Volume 2014
  • - Article ID 282147
  • - Review Article

Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells

Francesco Orio | Giovanna Muscogiuri | ... | Carmine Selleri
  • Special Issue
  • - Volume 2014
  • - Article ID 604685
  • - Review Article

Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders

Daniela Sorriento | Antonietta Valeria Pascale | ... | Guido Iaccarino
  • Special Issue
  • - Volume 2014
  • - Article ID 731462
  • - Research Article

Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats

Samah S. Abbas | Mona F. Schaalan | ... | Ezzeddin S. El-Denshary
  • Special Issue
  • - Volume 2014
  • - Article ID 946265
  • - Research Article

Detection of Impaired Cognitive Function in Rat with Hepatosteatosis Model and Improving Effect of GLP-1 Analogs (Exenatide) on Cognitive Function in Hepatosteatosis

Oytun Erbaş | Fulden Sarac | ... | Gönül Peker
  • Special Issue
  • - Volume 2014
  • - Article ID 251378
  • - Research Article

Evaluation of Lung and Bronchoalveolar Lavage Fluid Oxidative Stress Indices for Assessing the Preventing Effects of Safranal on Respiratory Distress in Diabetic Rats

Saeed Samarghandian | Reza Afshari | Aghdas Sadati
  • Special Issue
  • - Volume 2014
  • - Article ID 230835
  • - Research Article

A Novel Role of Globular Adiponectin in Treatment with HFD/STZ Induced T2DM Combined with NAFLD Rats

Hong Ma | Guo-Ping You | ... | Wen-Qiang Zhang
The Scientific World Journal
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Acceptance rate24%
Submission to final decision97 days
Acceptance to publication42 days
CiteScore1.430
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