Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study

Figure 2

Gross and microscopic images of tumours detected in TP53-modified pig B. (a): Large nephroblastoma tumour mass (arrow) in the left kidney. (b): Cross-section of the tumour in the left kidney. Scale bar = 5 cm. (c): Neoplastic lesion composed of blastemal cells, epithelial cells that formed tubular and primitive glomerular-like structures, and stromal components. The predominant component is the blastema. 100x magnification. (d): Image within the square is shown in Figure 2(c). The blastemal cells are arranged in solid sheets. They are small round-to-oval cells with scant cytoplasm. Epithelial cells showing tubular patterns (arrowheads). A primitive glomerular-like structure (arrow). Each tumour cell has scant cytoplasm and oval nuclei with mild-to-moderate atypia. However, the mitotic index remained low. 400x magnification.