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Advances in Materials Science and Engineering
Volume 2016, Article ID 3452171, 5 pages
http://dx.doi.org/10.1155/2016/3452171
Research Article

Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration

1Faculty of Veterinary Medicine, Banat’s University of Agricultural Sciences, 119 Calea Aradului, 300645 Timişoara, Romania
2Collagen Department, Leather and Footwear Research Institute, 93 Ion Minulescu Street, 031215 Bucharest, Romania
3Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy “Victor Babes”, Piata Eftimie Murgu 2, 300041 Timişoara, Romania
4Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania

Received 4 February 2016; Accepted 3 March 2016

Academic Editor: Mikhael Bechelany

Copyright © 2016 Narcisa Mederle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. S. S. Jee, “Integrated bone tissue physiology: anatomy and physiology,” in Bone Mechanics Handbook, S. C. Cowin, Ed., CRC Press, Boca Raton, Fla, USA, 2001. View at Google Scholar
  2. G. S. Baht, G. K. Hunter, and H. A. Goldberg, “Bone sialoprotein–collagen interaction promotes hydroxyapatite nucleation,” Matrix Biology, vol. 27, no. 7, pp. 600–608, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Singh, “Hydroxyapatite, a biomaterial: its chemical synthesis, characterization and study of biocompatibility prepared from shell of garden snail, Helix aspersa,” Bulletin of Materials Science, vol. 35, no. 6, pp. 1031–1038, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Z. LeGeros, “Calcium phosphate-based osteoinductive materials,” Chemical Reviews, vol. 108, no. 11, pp. 4742–4753, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Puppi, E. Chiellini, F. Chiellini, and A. M. Piras, “Polymeric materials for bone and cartilage repair,” Progress in Polymer Science, vol. 35, no. 4, pp. 403–440, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. N. K. Nga, T. T. Hoai, and P. H. Viet, “Biomimetic scaffolds based on hydroxyapatite nanorod/poly(D,L) lactic acid with their corresponding apatite-forming capability and biocompatibility for bone-tissue engineering,” Colloids and Surfaces B: Biointerfaces, vol. 128, pp. 506–514, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. C. R. Perry, “Bone repair techniques, bone graft, and bone graft substitutes,” Clinical Orthopaedics and Related Research, no. 360, pp. 71–86, 1999. View at Google Scholar · View at Scopus
  8. K. Alvarez and H. Nakajima, “Metallic scaffolds for bone regeneration,” Materials, vol. 2, no. 3, pp. 790–832, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Ficai, E. Andronescu, G. Voicu, D. Ficai, M. G. Albu, and A. Ficai, “Mollusc shell/collagen composite as potential biomaterial for bone substitutes,” Romanian Journal of Materials, vol. 40, no. 4, pp. 359–364, 2010. View at Google Scholar · View at Scopus
  10. I. O. Smith, X. H. Liu, L. A. Smith, and P. X. Ma, “Nanostructured polymer scaffolds for tissue engineering and regenerative medicine,” Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 1, no. 2, pp. 226–236, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. D. W. Hutmacher, “Scaffolds in tissue engineering bone and cartilage,” Biomaterials, vol. 21, no. 24, pp. 2529–2543, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Zhang and P. X. Ma, “Synthetic nano-fibrillar extracellular matrices with predesigned macroporous architectures,” Journal of Biomedical Materials Research, vol. 52, no. 2, pp. 430–438, 2000. View at Google Scholar · View at Scopus
  13. K. Gelse, E. Pöschl, and T. Aigner, “Collagens—structure, function, and biosynthesis,” Advanced Drug Delivery Reviews, vol. 55, no. 12, pp. 1531–1546, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. M. G. Patino, M. E. Neiders, S. Andreana, B. Noble, and R. E. Cohen, “Collagen: an overview,” Implant Dentistry, vol. 11, no. 3, pp. 280–285, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. M. G. Albu, I. Titorencu, and M. V. Ghica, “Collagen-based drug delivery systems for tissue engineering,” in Biomaterials Applications for Nanomedicine, R. Pignatello, Ed., chapter 17, pp. 333–358, InTech, Rijeka, Croatia, 2011. View at Publisher · View at Google Scholar
  16. V. Trandafir, G. Popescu, M. G. Albu, H. Iovu, and M. Georgescu, Bioproducts Based on Collagen, Ars Docendi Publishing House, 2007.
  17. T. Kobayashi, S. Nakamura, and K. Yamashita, “Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite,” Journal of Biomedical Materials Research, vol. 57, no. 4, pp. 477–484, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Injac, V. Djordjevic-Milic, and B. Srdjenovic, “Thermostability testing and degradation profiles of doxycycline in bulk, tablets, and capsules by HPLC,” Journal of Chromatographic Science, vol. 45, no. 9, pp. 623–628, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. B. A. Cunha, C. M. Sibley, and A. M. Ristuccia, “Doxycycline,” Therapeutic Drug Monitoring, vol. 4, no. 2, pp. 115–135, 1982. View at Google Scholar · View at Scopus
  20. M. Walter, M. Frank, M. Satue et al., “Bioactive implant surface with electrochemically bound doxycycline promotes bone formation markers in vitro and in vivo,” Dental Materials, vol. 30, no. 4, pp. 463–463, 2014. View at Google Scholar
  21. E. Kütan, G. Duygu-Çapar, C. Özçakir-Tomruk et al., “Efficacy of doxycycline release collagen membrane on surgically created and contaminated defects in rat tibiae: a histopathological and microbiological study,” Archives of Oral Biology, vol. 63, pp. 15–21, 2016. View at Publisher · View at Google Scholar
  22. M. G. Albu, M. V. Ghica, M. Leca et al., “Doxycycline delivery from collagen matrices crosslinked with tannic acid,” Molecular Crystals & Liquid Crystals, vol. 523, pp. 97/[669]–105/[677], 2010. View at Publisher · View at Google Scholar
  23. I. Titorencu, M. G. Albu, M. Giurginca et al., “In vitro biocompatibility of human endothelial cells with collagen-doxycycline matrices,” Molecular Crystals and Liquid Crystals, vol. 523, no. 1, pp. 82/654–96/668, 2010. View at Publisher · View at Google Scholar
  24. M. G. Albu, E. Kutan, M. Veshler, C. Ozcakir-Tomruk, I. Cristescu, and M. V. Ghica, “Efficacy of Doxicoll—a novel drug delivery systems for infected bone tissue,” European Cell and Materials, vol. 30, supplement 2, p. 39, 2015. View at Google Scholar
  25. S. Marin, M. M. Marin, A.-M. Ene et al., “Collagen-doxycycline spongious forms for infected tissues treatment,” in Proceedings of the 5th International Conference on Advanced Materials and Systems (ICAMS '14), pp. 249–254, Bucharest, Romania, October 2014.