Nanoliposomal L-Asparaginase and Its Antitumor Activities in Lewis Lung Carcinoma Tumor-Induced BALB/c Mice
Tumor growth after treatment with free L-ASP or liposomal L-ASP. BALB/c mice harboring tumors induced by LLC cells were treated with either free L-ASP (6 UI/mouse) or encapsulated L-ASP liposomes at either 6 UI/mouse or 3 UI/mouse (). Liposome-entrapped L-ASP at both doses 6 UI/mouse and 3 UI/mouse significantly inhibited tumor growth after 28 days compared with the negative control (blank liposome) ( and , respectively). Error bars represent standard error (SE).
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