Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm

Table 3

Quantification results of AML, HYD, and VAL in a mixture using the Kalman filter with the assumption of initial guesses method (Solution 2).

	Mixture	H1	H2	H3	H4
AML	Co (µg/mL)	0.250	0.50	1.00	5.00
	C (µg/mL)	0.300	0.300	0.282	0.477
	RE (%)	20.0	−40.0	−71.8	−90.5
HYD	Co (µg/mL)	0.325	0.650	1.300	5.000
	C (µg/mL)	0.301	0.304	0.368	0.443
	RE (%)	−7.4	−53.2	−71.7	−91.1
VAL	Co (µg/mL)	4.00	8.00	16.00	5.00
	C (µg/mL)	0.319	0.454	0.542	0.289
	RE (%)	−92.0	−94.3	−96.6	−94.2

C_o: concentration in the standard solution; C: calculated concentration.