Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm
Table 6
Method repeatability.
Mixture
AML
HYD
VAL
Rep 1
Rep 2
Rep 3
Rep 1
Rep 2
Rep 3
Rep 1
Rep 2
Rep 3
H1
C (µg/mL)
0.253
0.252
0.254
0.320
0.320
0.321
3.990
3.980
4.010
Cmean (µg/mL)
0.253
0.320
3.993
RSDmea (%)
0.4
0.3
0.4
1/2 RSDHorwitz (%)
9.9
9.5
6.5
H2
C (µg/mL)
0.511
0.510
0.514
0.646
0.645
0.650
8.060
8.044
8.109
Cmean (µg/mL)
0.5120
0.647
8.071
RSDmea (%)
0.4
0.5
0.4
1/2 RSDHorwitz (%)
6.3
8.6
5.9
H3
C (µg/mL)
1.016
1.013
1.020
1.290
1.286
1.296
16.050
15.994
16.114
Cmean (µg/mL)
1.016
1.291
16.053
RSDmea (%)
0.4
0.4
0.4
1/2 RSDHorwitz (%)
8.0
7.7
5.3
H4
C (µg/mL)
4.981
4.971
5.008
5.064
5.054
5.089
4.821
4.811
4.844
Cmean (µg/mL)
4.987
5.069
4.825
RSDmea (%)
0.4
0.4
0.4
1/2 RSDHorwitz (%)
6.3
6.3
6.3
RSDmea: RSD calculated from standard mixture measurement.