Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm

Table 7

Measured concentrations of AML, HYD, and VAL in Exforge HCT tablets employing the developed Kalman-Excel program.

Replicate samples	AML		HYD		VAL
	CAML (mg/mL)	Mass per tablet (mg)	CHYD (mg/mL)	Mass per tablet (mg)	CVAL (mg/mL)	Mass per tablet (mg)
B1	0.965	9.65	1.168	11.68	16.997	169.97
B2	0.980	9.80	1.186	11.86	17.249	172.49
B3	0.937	9.37	1.134	11.34	16.506	165.06
Cmean (mg/mL)	0.961	9.61	1.163	11.630	16.917	169.170
S	0.022	0.22	0.026	0.26	0.378	3.78
RSD %	2.3	2.3	2.2	2.2	2.2	2.2
1/2 RSDHorwitz (%)	8		5.5		5.3