Advances in Materials Science and Engineering

Research Article

Simultaneous Determination of Amlodipine, Hydrochlorothiazide, and Valsartan in Pharmaceutical Products by a Combination of Full Spectrum Measurement and Kalman Filter Algorithm

Table 9

Comparison of AML, HYD, and VAL contents in Exforge HCT tablet measured (n = 3) by using the developed method and HPLC method.


	AML		HYD		VAL
	Kalman	HPLC	Kalman	HPLC	Kalman	HPLC

X_mean (mg/tablet, n = 3)	9.61	9.51	11.66	11.63	169.17	167.66
S (mg/tablet. n = 3)	0.22	0.09	0.26	0.19	3.78	1.24
F_exp/F(0.05; 2; 2)	5.30/19		1.9/19		9.32/19
Sp	0.16		0.34		0.10
t_exp/t(0.05; f)	0.53/4.3		0.06/4.3		0.71/4.30
P	0.65		0.96		0.55

Kalman: the Kalman-Excel program combined with spectrophotometry method; F_exp: the experimental variance of the corresponding method; F (0.05; 2; 2): F distribution at alpha 0.05 and the respective degrees of freedom of numerator and denominator; S_p: pooled variance; t_exp: experimental t value; t(0.05; f = 4): t value at alpha 0.05 and 4 degrees of freedom.