Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications

Table 1

The application of chitosan-based nanocomposites in wound healing in recent years.

MNPs	Matrix	Delivery strategies	Results	Reference
Ag	Gelatine/CS	Scaffolds	(1) Good mechanical properties, water absorption, and moisture retention; (2) High antimicrobial activity against S. aureus and E. coli; (3) No cytotoxicity on fibroblast cells (L929)	[35]
Cu	Sodium alginate/cellulose/CS	Films	(1) High antibacterial properties against both MRSA and E. coli; (2) No cytotoxicity on fibroblast cells (L929) and human dermal fibroblasts	[36]
Ag	Collagen/CS	Scaffolds	Accelerated the process of wound healing, the proliferation of fibroblasts, neovascularization, and collagen deposition in mice	[37]
Ag	Moxifloxacin- (Mox-) loaded CS	Films	(1) Presented higher swelling ratio and lower tensile strength (TS) and better elongation at break (EB); (2) Good antibacterial properties against S. aureus, P. aeruginosa, and MRSA	[38]
Ag	Sanghuang polysaccharides/CS	Sponges	(1) Excellent swelling and water retention properties; (2) No cytotoxicity on L929 cells; (3) Promoted wound contraction and internal tissue growth in mice	[39]
Ag	CS	Films	(1) Showed significant antibacterial activity against Gram-negative E. coli, P. aeruginosa, and Gram-positive S. aureus; (2) Human fibroblasts (HF) displayed cell viability higher than 90%	[40]
Ag	PVA/CS	Hydrogels	(1) Higher antioxidant activity; (2) Low cytotoxicity effect against Chinese hamster ovary (CHO-K1) cells; (3) Significantly promoted wound healing in mice	[41]
Ag	PVA/graphene/CS	Hydrogels	Showed a significant decrease in inflammatory cells on histological examination	[42]
Ag/Cu	CS/PVA/hydroxyapatite	Nanofibres	Rapid haemostasis in mice	[43]
Cu	CS	Films	Released nitric oxide and promoted wound healing	[44]
ZnO	Collagen/CS	Nanofibres	Accelerated the healing of burn wounds in rats	[45]
ZnO	Keratin/CS	Hydrogel	Assisted rapid skin cell construction along with collagen development	[46]
ZnO	CS/PVA	Nanofibres	Effectively healed diabetic wounds faster	[47]