Tissue engineering is an important field of regenerative medicine for tissue repair. Tissue engineering covers a broad range of applications, in practice, the term is closely associated with applications that repair or replace portions of or whole tissues. There are so many potential applications to tissue engineering that the overall scale of the undertaking is enormous. The field is ripe for expansion and requires the training of a generation of materials scientists and chemical engineers. The optimal chemical and physical configurations of new biomaterials as they interact with living cells to produce tissue-engineered constructs are under study by many research groups. These biomaterials can be permanent or biodegradable. They can be naturally occurring, synthetic or hybrid materials. They need to be developed to be compatible with living systems or with living cells in vitro and in vivo. Their interface with the cells and the implant site must be clearly understood so that the interface can be optimized.

This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have been also aimed at replacing lost or severely damaged tissues or organs. However, the tissues regenerated by this tissue engineering and widely applied to patients are still very limited, including skin, bone, cartilage, capillary, and periodontal tissues. The principles of materials and cell transplantation to develop substitute tissues and/or promote endogenous regeneration. Tissue engineering involves the use of a tissue scaffold for the formation of new viable tissue for a medical purpose.

In this Special Issue, we encourage more research concerning the natural and biocompatible materials in dental and craniofacial tissue engineering. These materials can be considered as scaffolds for stimulating stem cell differentiation in tissue regeneration. We welcome original research articles (in vitro and in vivo) and review articles on biocompatible biomaterials and natural materials in dental and craniofacial tissue engineering and regenerative medicine.

Potential topics include but are not limited to the following:

• Natural and biomaterials in dental and craniofacial tissue engineering (in vitro, in vivo, and clinical studies)
• Antibacterial materials (biocompatible, biomaterials, and natural) help and accelerate the regeneration in dental and craniofacial tissue engineering (in vitro, in vivo, clinical studies)
• Materials (biocompatible, biomaterials and natural) for soft tissue healing (Epithelial, nerve and skin tissues, and so on) (in vitro, in vivo, clinical studies)
• Biocompatible biomaterials and natural for hard tissue healing (bone and dental, in vitro, in vivo, clinical studies)
• Cell and stem cell–material interaction studies, including mechano-biology aspects