Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 270985, 11 pages
http://dx.doi.org/10.1155/2010/270985
Research Article

Autocrine, Not Paracrine, Interferon-Gamma Gene Delivery Enhances Ex Vivo Antigen-Specific Cytotoxic T Lymphocyte Stimulation and Killing

1Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2Research and Therapy Center for Hepatic Diseases, The 2nd Affiliated Hospital, The 2nd Medical College, Chongqing Medical University, Chongqing 630046, China
3Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
4Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
5Central Arkansas Veterans Healthcare System, 111J, 4300 West 7th Street, Little Rock, AR 72205, USA

Received 30 November 2009; Accepted 24 February 2010

Academic Editor: Hanchun Yang

Copyright © 2010 Dazhi Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Pittet, J. Grimm, C. R. Berger et al., “In vivo imaging of T cell delivery to tumors after adoptive transfer therapy,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 30, pp. 12457–12461, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. J. R. Park, D. L. DiGiusto, M. Slovak et al., “Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma,” Molecular Therapy, vol. 15, no. 4, pp. 825–833, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Mackensen, N. Meidenbauer, S. Vogl, M. Laumer, J. Berger, and R. Andreesen, “Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma,” Journal of Clinical Oncology, vol. 24, no. 31, pp. 5060–5069, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. A. D. Santin, P. L. Hermonat, A. Ravaggi et al., “Development and therapeutic effect of adoptively transferred T cells primed by tumor lysate-pulsed autologous dendritic cells in a patient with metastatic endometrial cancer,” Gynecologic and Obstetric Investigation, vol. 49, no. 3, pp. 194–203, 2000. View at Google Scholar · View at Scopus
  5. A. D. Santin, P. L. Hermonat, A. Ravaggi et al., “Development, characterization and distribution of adoptively transferred peripheral blood lymphocytes primed by human papillomavirus 18 E7-pulsed autologous dendritic cells in a patient with metastatic adenocarcinoma of the uterine cervix,” European Journal of Gynaecological Oncology, vol. 21, no. 1, pp. 17–23, 2000. View at Google Scholar · View at Scopus
  6. A. Ribas, L. H. Butterfield, W. H. McBride et al., “Genetic immunization for the melanoma antigen MART-1/Melan-A using recombinant adenovirus-transduced murine dendritic cells,” Cancer Research, vol. 57, no. 14, pp. 2865–2869, 1997. View at Google Scholar · View at Scopus
  7. K. Murali-Krishna, J. D. Altman, M. Suresh, D. Sourdive, A. Zajac, and R. Ahmed, “In vivo dynamics of anti-viral CD8 T cell responses to different epitopes: an evaluation of bystander activation in primary and secondary responses to viral infection,” Advances in Experimental Medicine and Biology, vol. 452, pp. 123–142, 1998. View at Google Scholar · View at Scopus
  8. A. H. H. van Boxel-Dezaire and G. R. Stark, “Cell type-specific signaling in response to interferon-γ,” Current Topics in Microbiology and Immunology, vol. 316, pp. 119–154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Schoenborn and C. B. Wilson, “Regulation of interferon-γ during innate and adaptive immune responses,” Advances in Immunology, vol. 96, pp. 41–101, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Gattoni, A. Parlato, B. Vangieri, M. Bresciani, and R. Derna, “Interferon-γ: biologic functions and HCV therapy (type I/II) (1 of 2 parts),” Clinica Terapeutica, vol. 157, no. 4, pp. 457–468, 2006. View at Google Scholar · View at Scopus
  11. R. A. Corn, M. A. Aronica, F. Zhang et al., “T cell-intrinsic requirement for NF-?B induction in postdifferentiation IFN-? production and clonal expansion in a Th1 response,” Journal of Immunology, vol. 171, no. 4, pp. 1816–1824, 2003. View at Google Scholar · View at Scopus
  12. C. Scheibenbogen, P. Romero, L. Rivoltini et al., “Quantitation of antigen-reactive T cells in peripheral blood by IFN?-ELISPOT assay and chromium-release assay: a four-centre comparative trial,” Journal of Immunological Methods, vol. 244, no. 1-2, pp. 81–89, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. F. H. Rininsland, T. Helms, R. J. Asaad, B. O. Boehm, and M. Tary-Lehmann, “Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity,” Journal of Immunological Methods, vol. 240, no. 1-2, pp. 143–155, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. J. G. Segal, N. C. Lee, Y. L. Tsung, J. A. Norton, and K. Tsung, “The role of IFN-γ in rejection of established tumors by IL-12: source of production and target,” Cancer Research, vol. 62, no. 16, pp. 4696–4703, 2002. View at Google Scholar · View at Scopus
  15. S. Radhakrishnan, K. R. Wiehagen, V. Pulko et al., “Induction of a Th1 response from Th2-polarized T cells by activated dendritic cells: dependence on TCR:peptide-MHC interaction, ICAM-1, IL-12, and IFN-?,” Journal of Immunology, vol. 178, no. 6, pp. 3583–3592, 2007. View at Google Scholar · View at Scopus
  16. N. E. M. Van Emmerik, C. R. Daane, C. J. Knoop et al., “The avidity of allospecific cytotoxic T lymphocytes (CTL) determines their cytokine production profile,” Clinical and Experimental Immunology, vol. 110, no. 3, pp. 447–453, 1997. View at Google Scholar · View at Scopus
  17. M. Hofmann, M. Radsak, G. Rechtsteiner et al., “T cell avidity determines the level of CTL activation,” European Journal of Immunology, vol. 34, no. 7, pp. 1798–1806, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Fitzpatrick, A. P. Makrigiannis, M. Kaiser, and D. W. Hoskin, “Anti-CD3-activated killer T cells: interferon-γ and interleukin-10 cross-regulate granzyme B expression and the induction of major histocompatibility complex-unrestricted cytotoxicity,” Journal of Interferon and Cytokine Research, vol. 16, no. 7, pp. 537–546, 1996. View at Google Scholar · View at Scopus
  19. D. S.A. Webb and T. L. Gerrard, “IFN-α, and IFN-γ can affect both monocytes and tumor cells to modulate monocyte-mediated cytotoxicity,” Journal of Immunology, vol. 144, no. 9, pp. 3643–3648, 1990. View at Google Scholar · View at Scopus
  20. J. G. Williams, G. J. Jurkovich, G. B. Hahnel, and R. V. Maier, “Macrophage priming by interferon gamma: a selective process with potentially harmful effects,” Journal of Leukocyte Biology, vol. 52, no. 6, pp. 579–584, 1992. View at Google Scholar · View at Scopus
  21. S. M. F. Akbar, K. Kajino, K. Tanimoto, K.-I. Yamamura, M. Onji, and O. Hino, “Unique features of dendritic cells in IFN-γ transgenic mice: relevance to cancer development and therapeutic implications,” Biochemical and Biophysical Research Communications, vol. 259, no. 2, pp. 294–299, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Barnett, S. J. Goebel, M. A. Nothdurft, and J. J. Elting, “Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains,” Genomics, vol. 3, no. 1, pp. 59–66, 1988. View at Google Scholar · View at Scopus
  23. P. W. Gray, D. W. Leung, and D. Pennica, “Expression of human immune interferon cDNA in E. coli and monkey cells,” Nature, vol. 295, no. 5849, pp. 503–508, 1982. View at Google Scholar · View at Scopus
  24. Y. Liu, M. Chiriva-Internati, F. Grizzi et al., “Rapid induction of cytotoxic T-cell response against cervical cancer cells by human papillomavirus type 16 E6 antigen gene delivery into human dendritic cells by an adeno-associated virus vector,” Cancer Gene Therapy, vol. 8, no. 12, pp. 948–957, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. C.-X. You, Y. Liu, M. Shi, M. Cao, R.-C. Luo, and P. L. Hermonat, “Comparison of AAV/IL-7 autocrine (T cell) versus paracrine (DC) gene delivery for enhancing CTL stimulation and function,” Cancer Immunology, Immunotherapy, vol. 59, no. 5, pp. 779–787, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. I. Ha, W. S. Lane, and D. Reinberg, “Cloning of a human gene encoding the general transcription initiation factor IIB,” Nature, vol. 352, no. 6337, pp. 689–695, 1991. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Pala, T. Hussell, and P. J. M. Openshaw, “Flow cytometric measurement of intracellular cytokines,” Journal of Immunological Methods, vol. 243, no. 1-2, pp. 107–124, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Liu, A. D. Santin, M. Mane et al., “Transduction and utility of the granulocyte-macrophage colony-stimulating factor gene into monocytes and dendritic cells by adeno-associated virus,” Journal of Interferon and Cytokine Research, vol. 20, no. 1, pp. 21–30, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Chiriva-Internati, Y. Liu, J. A. Weidanz et al., “Testing recombinant adeno-associated virus-gene loading of dendritic cells for generating potent cytotoxic T lymphocytes against a prototype self-antigen, multiple myeloma HM1.24,” Blood, vol. 102, no. 9, pp. 3100–3107, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. S. M. F. Akbar, K. Kajino, K. Tanimoto, K.-I. Yamamura, M. Onji, and O. Hino, “Unique features of dendritic cells in IFN-γ transgenic mice: relevance to cancer development and therapeutic implications,” Biochemical and Biophysical Research Communications, vol. 259, no. 2, pp. 294–299, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Xu, K. Ariizumi, P. R. Bergstresser, and A. Takashima, “Cytokine-dependent regulation of growth and maturation in murine epidermal dendritic cell lines,” European Journal of Immunology, vol. 25, no. 4, pp. 1018–1024, 1995. View at Google Scholar · View at Scopus
  32. S. M. F. Akbar, K. Inaba, and M. Onji, “Upregulation of MHC class II antigen on dendritic cells from hepatitis B virus transgenic mice by interferon-γ: abrogation of immune response defect to a T-cell-dependent antigen,” Immunology, vol. 87, no. 4, pp. 519–527, 1996. View at Google Scholar · View at Scopus
  33. M. M. Moretto, L. M. Weiss, C. L. Combe, and I. A. Khan, “IFN-γ-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection,” Journal of Immunology, vol. 179, no. 4, pp. 2485–2492, 2007. View at Google Scholar · View at Scopus
  34. G. Lugo-Villarino, R. Maldonado-López, R. Possemato, C. Peñaranda, and L. H. Glimcher, “T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 13, pp. 7749–7754, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. T. K. Varma, C. Y. Lin, T. E. Toliver-Kinsky, and E. R. Sherwood, “Endotoxin-induced gamma interferon production: contributing cell types and key regulatory factors,” Clinical and Diagnostic Laboratory Immunology, vol. 9, no. 3, pp. 530–543, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Noble and D. M. Kemeny, “Interleukin-4 enhances interferon-γ synthesis but inhibits development of interferon-γ-producing cells,” Immunology, vol. 85, no. 3, pp. 357–363, 1995. View at Google Scholar · View at Scopus
  37. M.-L. Chen, B.-S. Yan, D. Kozoriz, and H. L. Weiner, “Novel CD8+ Treg suppress EAE by TGF-β- and IFN-γ-dependent mechanisms,” European Journal of Immunology, vol. 39, no. 12, pp. 3423–3435, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Fuessel, A. Meye, M. Schmitz et al., “Vaccination of hormone-refractory prostate cancer patients with peptide cocktail-loaded dendritic cells: results of a phase I clinical trial,” Prostate, vol. 66, no. 8, pp. 811–821, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. S. A. Rosenberg and M. E. Dudley, “Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, supplement 2, pp. 14639–14645, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. S. A. Rosenberg, N. P. Restifo, J. C. Yang, R. A. Morgan, and M. E. Dudley, “Adoptive cell transfer: a clinical path to effective cancer immunotherapy,” Nature Reviews Cancer, vol. 8, no. 4, pp. 299–308, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Street, A. M. Kaufmann, A. Vaughan et al., “Interferon-? enhances susceptibility of cervical cancer cells to lysis by tumor-specific cytotoxic T cells,” Gynecologic Oncology, vol. 65, no. 2, pp. 265–272, 1997. View at Publisher · View at Google Scholar · View at Scopus
  42. T. A. Fehniger, K. Suzuki, J. B. VanDeusen, M. A. Cooper, A. G. Freud, and M. A. Caligiuri, “Fatal leukemia in interleukin-15 transgenic mice,” Blood Cells, Molecules, and Diseases, vol. 27, no. 1, pp. 223–230, 2001. View at Publisher · View at Google Scholar · View at Scopus
  43. H. A. Young, D. M. Klinman, D. A. Reynolds et al., “Bone marrow and thymus expression of interferon-? results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies,” Blood, vol. 89, no. 2, pp. 583–595, 1997. View at Google Scholar · View at Scopus