Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 730421, 9 pages
http://dx.doi.org/10.1155/2014/730421
Research Article

The Interrelationship between Leukotriene B4 and Leukotriene-A4-Hydrolase in Collagen/Adjuvant-Induced Arthritis in Rats

1Laboratory of Pharmacology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, 05503-900 São Paulo, SP, Brazil
2Department of Physiology, Instituto de Biociencias, Universidade de São Paulo, Rua do Matão, Travessa 14, No. 321, 05508-090 São Paulo, SP, Brazil

Received 6 November 2013; Revised 7 January 2014; Accepted 8 January 2014; Published 20 February 2014

Academic Editor: Noriyoshi Sawabata

Copyright © 2014 Mariana Trivilin Mendes and Paulo Flavio Silveira. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Doan and E. Massarotti, “Rheumatoid arthritis: an overview of new and emerging therapies,” Journal of Clinical Pharmacology, vol. 45, no. 7, pp. 751–762, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. I. B. McInnes and G. Schett, “The pathogenesis of rheumatoid arthritis,” The New England journal of medicine, vol. 365, no. 23, pp. 2205–2219, 2011. View at Google Scholar · View at Scopus
  3. D. L. Scott, F. Wolfe, and T. W. J. Huizinga, “Rheumatoid arthritis,” The Lancet, vol. 376, no. 9746, pp. 1094–1108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. H. L. Rosenzweig, M. M. Jann, T. T. Glant et al., “Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis,” Journal of Leukocyte Biology, vol. 85, no. 4, pp. 711–718, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Hu, W. Cheng, W. Cai, Y. Yue, J. Li, and P. Zhang, “Advances in research on animal models of rheumatoid arthritis,” Clinical Rheumatology, vol. 32, no. 2, pp. 161–165, 2013. View at Publisher · View at Google Scholar
  6. L. K. Myers, E. F. Rosloniec, M. A. Cremer, and A. H. Kang, “Minireview: collagen-induced arthritis, an animal model of autoimmunity,” Life Sciences, vol. 61, no. 19, pp. 1861–1878, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. M. T. Mendes, S. Murari-do-Nascimento, I. R. Torrigo, R. F. Alponti, S. C. Yamasaki, and P. F. Silveira, “Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis,” Regulatory Peptides, vol. 167, no. 2-3, pp. 215–221, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. S. C. Yamasaki, S. Murari-do-Nascimento, and P. F. Silveira, “Neutral aminopeptidase and dipeptidyl peptidase IV in the development of collagen II-induced arthritis,” Regulatory Peptides, vol. 173, no. 1–3, pp. 47–54, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Kim, J. Bang, H. W. Chang et al., “Anti-inflammatory effect of quetiapine on collagen-induced arthritis of mouse,” European Journal of Pharmacology, vol. 678, no. 1–3, pp. 55–60, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. T. D. Penning, M. A. Russell, B. B. Chen et al., “Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid,” Journal of Medicinal Chemistry, vol. 45, no. 16, pp. 3482–3490, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Z. Haeggström and A. Wetterholm, “Enzymes and receptors in the leukotriene cascade,” Cellular and Molecular Life Sciences, vol. 59, no. 5, pp. 742–753, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. P. C. Rudberg, F. Tholander, M. Andberg, M. M. G. M. Thunnissen, and J. Z. Haeggström, “Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates,” The Journal of Biological Chemistry, vol. 279, no. 26, pp. 27376–27382, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Foulon, S. Cadel, and P. Cohen, “Aminopeptidase B (EC 3.4.11.6),” International Journal of Biochemistry and Cell Biology, vol. 31, no. 7, pp. 747–750, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Cadel, T. Foulon, A. Viron et al., “Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 7, pp. 2963–2968, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Poras, S. Duquesnoy, M. C. Fournié-Zaluski, C. Ratinaud-Giraud, B. P. Roques, and T. Ouimet, “A sensitive fluorigenic substrate for selective in-vitro and in-vivo assay of Leukotriene A4 hydrolase activity,” Analytical Biochemistry, vol. 441, no. 2, pp. 152–161, 2013. View at Publisher · View at Google Scholar
  16. A. Panchaud, L. Avois, M. Roulet et al., “A validated liquid chromatography-mass spectrometry method for the determination of leukotrienes B4 and B5 produced by stimulated human polymorphonuclear leukocytes,” Analytical Biochemistry, vol. 341, no. 1, pp. 58–68, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. P. C. Rudberg, F. Tholander, M. M. G. M. Thunnissen, B. Samuelsson, and J. Z. Haeggström, “Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 7, pp. 4215–4220, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. G. E. Carpagnano, G. P. Palladino, D. Lacedonia, A. Koutelou, S. Orlando, and M. P. Foschino-Barbaro, “Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8,” BMC Cancer, vol. 11, article 226, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. A. Cremer, E. F. Rosloniec, and A. H. Kang, “The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease,” Journal of Molecular Medicine, vol. 76, no. 3-4, pp. 275–288, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Grage-Griebenow, J. Baran, H. Loppnow et al., “An Fcγ receptor I (CD64)-negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen-activated CD4-positive cytotoxic T cells,” European Journal of Immunology, vol. 27, no. 9, pp. 2358–2365, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. A. M. Liang, E. Claret, J. Ouled-Diaf et al., “Development of a homogeneous time-resolved fluorescence leukotriene B4 assay for determining the activity of leukotriene A4 hydrolase,” Journal of Biomolecular Screening, vol. 12, no. 4, pp. 536–545, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Takamoto, T. Yano, T. Shintani, and S. Hiraku, “A highly sensitive and selective method for the determination of Leukotriene B4 in human plasma by negative ion chemical ionization/gas chromatography/tandem mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 13, no. 12, pp. 1465–1472, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Erlandsson Harris, M. Liljeström, and L. Klareskog, “Characteristics of synovial fluid effusion in collagen-induced arthritis (CIA) in the DA rat; a comparison of histology and antibody reactivities in an experimental chronic arthritis model and rheumatoid arthritis (RA),” Clinical and Experimental Immunology, vol. 107, no. 3, pp. 480–484, 1997. View at Google Scholar · View at Scopus
  24. J. Gut, D. W. Goldman, G. C. Jamieson, and J. R. Trudell, “Conversion of leukotriene A4 to leukotriene B4: catalysis by human liver microsomes under anaerobic conditions,” Archives of Biochemistry and Biophysics, vol. 259, no. 2, pp. 497–509, 1987. View at Google Scholar · View at Scopus
  25. T. G. Brock, R. W. McNish, M. B. Bailie, and M. Peters-Golden, “Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence,” The Journal of Biological Chemistry, vol. 272, no. 13, pp. 8276–8280, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. P. T. Bozza, W. Yu, J. F. Penrose, E. S. Morgan, A. M. Dvorak, and P. F. Weller, “Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation,” Journal of Experimental Medicine, vol. 186, no. 6, pp. 909–920, 1997. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Hirabayashi, K. Kume, K. Hirose et al., “Critical duration of intracellular CA2+ response required for continuous translocation and activation of cytosolic phospholipase A2,” The Journal of Biological Chemistry, vol. 274, no. 8, pp. 5163–5169, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Hedi and G. Norbert, “5-Lipoxygenase pathway, dendritic cells, and adaptive immunity,” Journal of Biomedicine and Biotechnology, vol. 2004, no. 2, pp. 99–105, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Yokomizo, T. Izumi, and T. Shimizu, “Leukotriene B4: metabolism and signal transduction,” Archives of Biochemistry and Biophysics, vol. 385, no. 2, pp. 231–241, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. S.-E. Dahlen, J. Z. Haeggstrom, B. Samuelsson, K. F. Rabe, and A. R. Leff, “Leukotrienes as targets for treatment of asthma and other diseases: current basic and clinical research,” American Journal of Respiratory and Critical Care Medicine, vol. 161, pp. S25–S31, 2000. View at Publisher · View at Google Scholar
  31. O. Werz, “5-lipoxygenase: cellular biology and molecular pharmacology,” Current Drug Target, vol. 1, no. 1, pp. 23–44, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Chen, B. K. Lam, A. D. Luster et al., “Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis,” Journal of Immunology, vol. 185, no. 9, pp. 5503–5511, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. P.-J. Jakobsson, B. Odlander, and H.-E. Claesson, “Effects of monocyte-lymphocyte interaction on the synthesis of leukotriene B4,” European Journal of Biochemistry, vol. 196, no. 2, pp. 395–400, 1991. View at Google Scholar · View at Scopus
  34. L. Iversen, “Purification and characterization of leukotriene A4 hydrolase from human epidermis,” FEBS Letters, vol. 358, no. 3, pp. 316–322, 1995. View at Publisher · View at Google Scholar · View at Scopus
  35. D. A. Munafo, K. Shindo, J. R. Baker, and T. D. Bigby, “Leukotriene A4 hydrolase in human bronchoalveolar lavage fluid,” Journal of Clinical Investigation, vol. 93, no. 3, pp. 1042–1050, 1994. View at Google Scholar · View at Scopus
  36. H.-E. Claesson and J. Haeggstrom, “Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4,” European Journal of Biochemistry, vol. 173, no. 1, pp. 93–100, 1988. View at Google Scholar · View at Scopus
  37. J. A. Maclouf and R. C. Murphy, “Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4,” The Journal of Biological Chemistry, vol. 263, no. 1, pp. 174–181, 1988. View at Google Scholar · View at Scopus
  38. A. J. Barret, N. D. Rawlings, and J. F. Woessner, Handbook of Proteolytic Enzymes, Academic Press, London, UK, 1st edition, 1998.
  39. F. A. Fitzpatrick, R. Lepley, L. Orning, and K. Duffin, “Suicide inactivation of leukotriene A4 hydrolase/aminopeptidase,” Annals of the New York Academy of Sciences, vol. 744, pp. 31–38, 1994. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Hashimoto, H. Endo, I. Hayashi et al., “Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis,” Journal of Rheumatology, vol. 30, no. 8, pp. 1712–1718, 2003. View at Google Scholar · View at Scopus
  41. S. P. Mathis, V. R. Jala, D. M. Lee, and B. Haribabu, “Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis,” Journal of Immunology, vol. 185, no. 5, pp. 3049–3056, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Xu, H. Lu, J. Lin, Z. Chen, and D. Jiang, “Regulation of TNFα and IL1β in rheumatoid arthritis synovial fibroblasts by leukotriene B4,” Rheumatology International, vol. 30, no. 9, pp. 1183–1189, 2010. View at Publisher · View at Google Scholar · View at Scopus