BioMed Research International

Research Article

Genetic Diversity of Mycobacterium tuberculosis Complex Isolated from Tuberculosis Patients in Bahir Dar City and Its Surroundings, Northwest Ethiopia

Table 2

Spoligotype patterns of 44 shared types and their corresponding lineages/sublineages identified from a total of 168 Mycobacterium tuberculosis complex strains isolated in the Bahir Dar region.
SITIsolates with similar patternSITVIT2 lineage/sublineageCBN lineageOctal numberBinary format
201LAM1EA677777607760771
354Ural-1EA777737777420771
371T3EA777737777760771
413TurkeyEA777777404760771
503H3EA777777777720771
511TEA777777777760700
521T2EA777777777760731
536TEA777777777760771
543Manu2EA777777777763771
931LAM5EA777737607760771
13412H3EA777777777720631
1372X2EA777776777760601
1495T3-ETHEA777000377760771
1683H3EA777777777720671
2051TEA737777777760771
3361X1EA777776777760731
6991H3EA677777777720571
7771Ural-1EA777777777420771
8171Ural-1EA777777777420731
11661TEA777377777760771
15521H1EA777777774020631
16881TEA777777403760771
18771TEA737377777760771
20071T3EA777737677760771
24091T3EA777737757760771
31341H3EA777737377720771
34118T3-ETHEA777002377760771
34122T4EA777003377760771
212CAS1-KiliEAI703377400001771
257CAS1-DelhiEAI703777740003171
262CAS1-DelhiEAI703777740003771
28928CAS1-DelhiEAI703777740003571
7541CAS1-DelhiEAI503777740003771
9522CAS1-DelhiEAI603777740003771
12002UnknownEAI703777747777771
15511CAS1-DelhiEAI701777740003771
23592CAS1-DelhiEAI703677740003171
3431UnknownM. africanum700000007175771
9101UnknownM. africanum700000007177771
17291UnknownM. africanum700000004177771
34091AFRIM. africanum700020047177771
6651BOV_1M. bovis616773777777600
9821BOVM. bovis416773777777600
5231Manu_ancestIO777777777777771
CBN: conformal Bayesian network; unknown: designates patterns with signatures that do not belong to any of the major lineages/sublineages described in the SITVIT2 database. The 168 isolates were grouped into 89 different spoligotype patterns (strains). Of the total 89 strains, 44 strains (patterns) have already been registered in the SITVIT2 database (Table 2), while the remaining 45 patters were orphans and presented in Table 3. The dominant strains were SIT289 (28 isolates), SIT134 (12 isolates), and SIT3411 (8 isolates) (Table 2). Furthermore, the 168 isolates were grouped into five different lineages including the Euro-American, East-African Indian, M. africanum, Indo-Oceanic, and M. bovis lineages in the order of decreasing percentage.