In the last twenty years, minimal intervention (MI) has become one of the most important advances in dentistry. MI has gained worldwide popularity among dental practitioners, as the main benefits of this concept include improvements in the quality of various dental materials, and a better understanding of the mechanism of occurring dental caries. Furthermore, the MI concept advocates the remineralisation of non-cavitated enamel, dentin lesions with the surgical removal of enamel, and dentin tissues. Moreover, for MI, conservative cavity preparation is more recommended than the extension of prevention concepts.

Many encouraging results have been obtained in regard to the remineralisation efficacy of currently available remineralising agents in vitro. However, the clinical application of these materials showed a weak remineralisation performance which has been noticed in vitro, when adopting advanced techniques for monitoring the actual remineralizing capacity of the tested remineralisation agents. The aforementioned phenomenon can be caused by the environment of the oral cavity, that includes; a continuous change in the saliva pH, oral cavity temperature, disturbance in salivary flow, increased Streptococcus mutans load in saliva, and other factors that render the oral cavity a harsh environment for the remineralisation process to be successful.

The aim of this Special Issue is to collate original research articles, as well as review articles, discussing the various innovative techniques, and materials that will lead to the advancement of minimal intervention. Submissions highlighting innovative mineralizing agents, bioactive materials, enamel sealer materials that protects enamel from acidic attacks, techniques improving the durability of various dental adhesive materials, and methods used to protect the enamel in high caries risk patients are particularly encouraged.

Potential topics include but are not limited to the following:

• Application of spectroscopy in determining the mineral content of enamel, and dentin
• Application of spectroscopy in determining the degree of conversion of dental resins
• Application of spectroscopy in examining the mineral content of bone
• Detection of nanoleakage in the interface between dental adhesive resins, and coronal dental hard tissues
• Detection of nanoleakage between root sealers, and dentin root canal surfaces
• Detection of bioactivity of materials upon storage in various storage solution
• Interaction between enamel, dentin, cementum, and bioactive materials
• Detection of mineral release from various dental materials
• Detection of dental materials degradation upon exposure to various simulations of oral environment challenges
• Durability, and efficacy of using bioactive resin materials in restoring dental defects