BioMed Research International

Animal Models of Human Pathology 2020

Publishing date
01 Jan 2021
Submission deadline
11 Sep 2020

Lead Editor

1Institute of Experimental Endocrinology and Oncology, Naples, Italy

2Santiago University, Santiago de Compostela, Spain

3Sapienza University of Rome, Rome, Italy

Animal Models of Human Pathology 2020


Based on the genetic alterations found in humans, multiple models of human pathologies have been generated in genetically engineered or drug-induced animals. These experimental models are valuable tools for understanding the physiopathology of the disease and discovering novel therapeutic targets and drugs. In fact, one avenue holding tremendous potential to find therapies against human diseases is the use of intact living systems, where complex biological processes can be examined.

The aim of this Special Issue is to collate original research articles as well as review articles that will stimulate continuing efforts in developing animal models, ranging from invertebrates to large animals, to be used in preclinical applications, improving therapy in various fields of medicine (oncology, cardiovascular, immunology, endocrinology, brain pathologies, etc.). We are particularly interested in manuscripts that report naturally occurring, induced, or engineered animal models of human diseases and their preclinical applications. Reviews that summarize all animal models for a particular pathology, their involvement in preclinical trials, and their future in treatment practice are also particularly welcome.

Potential topics include but are not limited to the following:

  • Modeling glioblastoma in rodents
  • The use of animal models in the study of obesity
  • The value of animal models for drug development in autoimmune diseases
  • The genetics of cardiovascular disease: new insights from animal models
  • Understanding the pathogenesis and therapy of ataxia telangiectasia (AT) via animal models
  • Experimental animal models of rheumatoid arthritis, lupus erythematosus, and osteoarthritis
  • Small model organisms for neurodegenerative diseases
  • Large animal models of heart failure
  • The pig: a representative animal model for humans
  • Modeling human disease using the nematode Caenorhabditis elegans
  • Drosophila model of human diseases
  • Zebrafish models in oncology
  • Humanized mice to mimic human immune system
  • CRISPR/Cas9 animal models


  • Special Issue
  • - Volume 2022
  • - Article ID 9839314
  • - Editorial

Animal Models of Human Pathology 2020

Monica Fedele | Oreste Gualillo | Andrea Vecchione
  • Special Issue
  • - Volume 2021
  • - Article ID 8870674
  • - Research Article

Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2

Wei Zhao | Youyang Wu | ... | Wenbing Jiang
  • Special Issue
  • - Volume 2021
  • - Article ID 8851888
  • - Research Article

Development of Microsatellite Marker System to Determine the Genetic Diversity of Experimental Chicken, Duck, Goose, and Pigeon Populations

Xiulin Zhang | Yang He | ... | Zhenwen Chen
  • Special Issue
  • - Volume 2020
  • - Article ID 3193725
  • - Research Article

Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse Model

Faleh Alqahtani | Mohammed A. Assiri | ... | Faisal F. Alamri
  • Special Issue
  • - Volume 2020
  • - Article ID 5389731
  • - Research Article

Effect of Selenium on Expression of Apoptosis-Related Genes in Cryomedia of Mice Ovary after Vitrification

Reza Nori-Garavand | Maryam Hormozi | ... | Mandana Beigi Boroujeni
  • Special Issue
  • - Volume 2020
  • - Article ID 3403489
  • - Research Article

A Modified Murine Calvarial Osteolysis Model Exposed to Ti Particles in Aseptic Loosening

Zhantao Deng | Shuai Wang | ... | Qiujian Zheng
  • Special Issue
  • - Volume 2020
  • - Article ID 6403482
  • - Research Article

Impact of Acute Pancreatic Injury on Sphingolipid Metabolism in the Salivary Glands

Małgorzata Żendzian-Piotrowska | Dominika M. Ziembicka | ... | Krzysztof Kurek
  • Special Issue
  • - Volume 2020
  • - Article ID 7402645
  • - Research Article

Resveratrol Improves Hepatic Redox Status and Lipid Balance of Neonates with Intrauterine Growth Retardation in a Piglet Model

Kang Cheng | Shuli Ji | ... | Tian Wang
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.