BioMed Research International

Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Mechanism and Therapies


Publishing date
04 Jul 2014
Status
Published
Submission deadline
14 Feb 2014

Lead Editor

1Department of Neurosurgery, Kaohsiung Medical University, Kaohsiung, Taiwan

2Department of Neurosurgery, Tulane University, New Orleans, LA 70112, USA

3Departments of Neurosurgery, Physiology, and Anesthesiology, Loma Linda University, School of Medicine, Loma Linda, CA 92354, USA

4Department of Neurosurgery, University of Cincinnati, Cincinnati, OH 45219, USA

5Kantonsspital Aarau, Aarau, Switzerland


Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Mechanism and Therapies

Description

Subarachnoid hemorrhage- (SAH-) induced cerebral vasospasm is still a major cause of mortality and morbidity in patients with rupture of intracranial aneurysms. The most important and critical aspects of SAH-induced cerebral vasospasm is its failure to consistently respond to treatment. Despite the advances in pharmacological interventions, only partial success could be achieved in both experimental models and clinical trials. Although cerebral vasospasm associated with SAH has been recognized for more than half a century, the pathophysiological mechanism contributing to this form of arterial dysfunction is still illusive and more basic and clinical research is necessary to elucidate the underlying mechanisms. In addition to cerebral vasospasm, SAH-induced secondary brain injury may also contribute to a poor outcome. Accumulating data have suggested that apoptosis is a key mediator of secondary brain injury after SAH. Approximately 50% of SAH survivors remain permanently disabled because of cognitive dysfunction and do not return to their previous functions. Vasospasm alone could not explain the whole subtle changes in behavior and memory. In this aspect, apoptosis induced by global ischemia should be taken into consideration. A burgeoning number of studies have implied the impact of secondary brain injury in patients after aneurysmal SAH.

We invite investigators to contribute original research and review articles that will stimulate the continuing efforts to understand the pathophysiological mechanism of SAH-induced vasospasm and secondary brain injury, the development of strategies to treat these conditions, and the evaluation of outcomes. Potential topics include, but are not limited to:

  • The mechanism of vasospasm and secondary brain injury after aneurysmal SAH
  • The role of arterioles in the development of vasospasm after aneurysmal SAH
  • The role of early brain injury in vasospasm and secondary brain injury after aneurysmal SAH
  • Triple-H management in the treatment of vasospasm after aneurysmal SAH
  • Endovascular treatment strategies for vasospasm after aneurysmal SAH
  • The outcome and long-term complications after aneurysmal SAH
  • Translational Medicine: Animal study to clinical application

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/neurology/cv/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 679014
  • - Editorial

Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Mechanism and Therapies

Chih-Lung Lin | Aaron S. Dumont | ... | Carl Muroi
  • Special Issue
  • - Volume 2014
  • - Article ID 836397
  • - Research Article

Upregulation of Relaxin after Experimental Subarachnoid Hemorrhage in Rabbits

Yuichiro Kikkawa | Satoshi Matsuo | ... | Tomio Sasaki
  • Special Issue
  • - Volume 2014
  • - Article ID 927803
  • - Research Article

Patient Outcomes following Subarachnoid Hemorrhage between the Medical Center and Regional Hospital: Whether All Patients Should Be Transferred to Medical Centers

Tsung-Ying Lin | Chieh Hsin Wu | ... | Chih-Lung Lin
  • Special Issue
  • - Volume 2014
  • - Article ID 161702
  • - Research Article

The Role of Microclot Formation in an Acute Subarachnoid Hemorrhage Model in the Rabbit

Lukas Andereggen | Volker Neuschmelting | ... | Serge Marbacher
  • Special Issue
  • - Volume 2014
  • - Article ID 858496
  • - Review Article

The Harmful Effects of Subarachnoid Hemorrhage on Extracerebral Organs

Sheng Chen | Qian Li | ... | John H. Zhang
  • Special Issue
  • - Volume 2014
  • - Article ID 384342
  • - Review Article

Inflammation, Vasospasm, and Brain Injury after Subarachnoid Hemorrhage

Brandon A. Miller | Nefize Turan | ... | Gustavo Pradilla
  • Special Issue
  • - Volume 2014
  • - Article ID 531508
  • - Research Article

Alteration of Basilar Artery Rho-Kinase and Soluble Guanylyl Cyclase Protein Expression in a Rat Model of Cerebral Vasospasm following Subarachnoid Hemorrhage

Chih-Jen Wang | Pei-Yu Lee | ... | Aij-Lie Kwan
  • Special Issue
  • - Volume 2014
  • - Article ID 628597
  • - Review Article

To Look Beyond Vasospasm in Aneurysmal Subarachnoid Haemorrhage

Giulia Cossu | Mahmoud Messerer | ... | Roy Thomas Daniel
  • Special Issue
  • - Volume 2014
  • - Article ID 207616
  • - Research Article

Progesterone Attenuates Experimental Subarachnoid Hemorrhage-Induced Vasospasm by Upregulation of Endothelial Nitric Oxide Synthase via Akt Signaling Pathway

Chia-Mao Chang | Yu-Feng Su | ... | Chih-Lung Lin
  • Special Issue
  • - Volume 2014
  • - Article ID 253746
  • - Review Article

The Role of Arterioles and the Microcirculation in the Development of Vasospasm after Aneurysmal SAH

Masato Naraoka | Naoya Matsuda | ... | Hiroki Ohkuma
BioMed Research International
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Acceptance rate31%
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