BioMed Research International

Molecular Mechanism of Rheumatic Diseases and Efficacy of Current Therapies


Status
Published

Lead Editor

1Washington State University, Spokane, USA

2Emory University, Atlanta, USA

3Northeast Ohio Medical University, Rootstown, USA


Molecular Mechanism of Rheumatic Diseases and Efficacy of Current Therapies

Description

Arthritis is a condition which affects joints as well as tissues surrounding the joints and other connective tissues. It affects more than one in five adults and is the most common cause of disability in the USA. It occurs often in people with chronic conditions, such as heart disease and diabetes, as well as those who are obese. It broadly covers juvenile arthritis, fibromyalgia, gout, osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus (SLE), and so forth. The inflammatory process is mediated through a complex network of cytokines and chemokines, which is not yet completely understood.

In recent decades, there is emerging evidence showing the epigenetic modifications of the genome and miRNAs as the potential therapeutic targets in autoimmune diseases. Change of metabolic homeostatic condition also greatly influences the severity of disease etiology. Recent therapeutic approaches targeting metabolomics have shown promises at both genetic reprograming and disease dynamics at cellular levels or organ levels. However, understanding the role of important genetic changes and biochemistry behind these changes in autoimmune diseases, for suppressing inflammation and tissue destruction, is need of an hour in the era of personalized medicine.

We invite investigators to contribute original research articles as well as review articles that will highlight the pathogenesis of disease, biomarkers, and therapeutic intervention to manage the disease.

Potential topics include but are not limited to the following:

  • Understanding biomarkers or metabolic markers in the pathogenesis of rheumatic disease
  • Role of genetic changes such as haploinsufficiency, microRNA, epigenetic imprinting, and functional gene expression in the immunological affairs and its prevention of autoimmunity
  • Recent advancement in the technology for diagnosis of disease in patients and animal model

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2401329
  • - Editorial

Molecular Mechanism of Rheumatic Diseases and Efficacy of Current Therapies

Sadiq Umar | Abdul M. Tyagi | ... | Abdul Haseeb
  • Special Issue
  • - Volume 2017
  • - Article ID 2690402
  • - Research Article

Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Rheumatoid Arthritis

Inês P. Perpétuo | Joana Caetano-Lopes | ... | João E. Fonseca
  • Special Issue
  • - Volume 2017
  • - Article ID 7183516
  • - Research Article

PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue

P. Klinger | S. Lukassen | ... | K. Gelse
  • Special Issue
  • - Volume 2016
  • - Article ID 7296125
  • - Review Article

Gray Matter Atrophy within the Default Mode Network of Fibromyalgia: A Meta-Analysis of Voxel-Based Morphometry Studies

Chemin Lin | Shwu-Hua Lee | Hsu-Huei Weng
  • Special Issue
  • - Volume 2016
  • - Article ID 7407919
  • - Research Article

Immunosuppressive Treatment for Lupus Nephritis: Long-Term Results in 178 Patients

Elena V. Zakharova | Tatiana A. Makarova | ... | Ekaterina S. Stolyarevich
  • Special Issue
  • - Volume 2016
  • - Article ID 4193538
  • - Clinical Study

The -174G/C Interleukin-6 Gene Promoter Polymorphism as a Genetic Marker of Differences in Therapeutic Response to Methotrexate and Leflunomide in Rheumatoid Arthritis

A. J. Ruiz-Padilla | J. I. Gamez-Nava | ... | L. Gonzalez-Lopez
  • Special Issue
  • - Volume 2016
  • - Article ID 2503703
  • - Research Article

Effects of Berberine on NLRP3 and IL-1β Expressions in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation

Ya-Fei Liu | Cai-Yu-Zhu Wen | ... | Sheng-Hao Tu
  • Special Issue
  • - Volume 2016
  • - Article ID 7842587
  • - Review Article

Association between Toll-Like Receptor 4 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-Analysis

Weiping Hu | Senchao Wu | ... | Hongbin Zhong
  • Special Issue
  • - Volume 2016
  • - Article ID 4186027
  • - Research Article

Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161+Th1 Cells) to CD161+Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients

Shigeru Kotake | Yuki Nanke | ... | Hisashi Yamanaka
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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