BioMed Research International

Accelerating Precision Medicine through Integrated Analysis of Multiscale Biological Data


Publishing date
01 Mar 2022
Status
Closed
Submission deadline
15 Oct 2021

Lead Editor

1Shanghai Jiao Tong University, Shanghai, China

2Tongji University School of Medicine, Shanghai, China

3Wright State University, Dayton, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Accelerating Precision Medicine through Integrated Analysis of Multiscale Biological Data

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Precision medicine is a new medical model which proposes the customization of healthcare with clinical decisions, therapeutic schemes, and medical practices. In precision medicine, disease diagnosis is often applied to choose optimal and suitable therapies dependent on genome information or other molecular or cellular analysis of the patient. In recent years, with the advent and development of multiple sequencing methods, especially next-generation sequencing (NGS), fundamental achievements have accumulated to provide the opportunity to move towards a variety of innovative strategies. These include integrative bioinformatics analyses, with different computational toolsets, using multiscale biological data, and ever-increasing improvements in disease modeling for diagnosis, testing, and therapeutic intervention. Therefore, multiscale biological data in support of precision medicine has become increasingly commonplace and can provide a deeper understanding of the molecular processes of diseases.

However, precision medicine still encounters some barriers, including the integration of clinical and biological information, the development of accurate measurement methods, finding precise biomarkers, and choosing the optimal therapy. In addition, in the field of oncology, tumor relapse due to currently unknown causes, tumor heterogeneity, real-time monitoring for treatment efficacy, and unexpected drug resistance are all challenges that need to be addressed.

Therefore, the aim of this Special Issue on precision medicine is to provide a collection of multidisciplinary research or review articles integrating different scale data, with a focus on the integration of clinical and biological information, advanced accurate analytical methods, and novel biomarkers, as well as the application of disease modeling.

Potential topics include but are not limited to the following:

  • Precise molecular typing of diseases
  • Biomarker discovery for diseases
  • Predictive models for diagnosis, treatment, and prognosis
  • Novel computational methods for precision medicine
  • Development and application of disease models, including patient-derived xenografts or organoids
  • Antibody drug development
  • Single-cell sequencing for exploring the potential molecular mechanisms of diseases
  • Immunotherapy for diseases using integrated multiscale biological data
  • Liquid biopsy for monitoring disease development and curative effects
  • Translational medicine

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 1948657
  • - Research Article

Radiosensitizing Effect of Celastrol by Inhibiting G2/M Phase Arrest Induced by the c-myc Gene of Human SW1353 Chondrosarcoma Cells: Network and Experimental Analyses

Jin Qian | Zhen Zhang | ... | Tao Xie
  • Special Issue
  • - Volume 2022
  • - Article ID 6589651
  • - Research Article

The Function of circRNA-0047604 in Regulating the Tumor Suppressor Gene DACH1 in Breast Cancer

Bingkun Zhao | Rong Zhou | ... | Lin Fang
  • Special Issue
  • - Volume 2022
  • - Article ID 2972617
  • - Research Article

Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

Yan Ma | Yanbo Ma | ... | Zhigang Sun
  • Special Issue
  • - Volume 2022
  • - Article ID 5984184
  • - Research Article

Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB

Yuexia Yang | Guoming Li | Ruiqin Zhang
  • Special Issue
  • - Volume 2021
  • - Article ID 3347949
  • - Research Article

Effects of Sevoflurane on Apoptosis of Myocardial Cells in IRI Rats

Shikun Zhang | Xiaoyan Du | ... | Haiyan Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 1382061
  • - Research Article

miR-10b-5p Suppresses the Proliferation and Invasion of Primary Hepatic Carcinoma Cells by Downregulating EphA2

Xu Niu | Haitao Sun | ... | Wei Han
  • Special Issue
  • - Volume 2021
  • - Article ID 8544914
  • - Research Article

lncRNA FGD5-AS1 and miR-130a Can Be Used for Prognosis Analysis of Patients with Chronic Periodontitis

Miao Yu | Chunyuan Chi
  • Special Issue
  • - Volume 2021
  • - Article ID 5854056
  • - Research Article

Analysis on the Clinical Effect of High-Dose Glucocorticoids Combined with Immunosuppressants on Patients with Myasthenia Gravis Undergoing Video-Assisted Thoracoscopic Surgery

Pei Liu | Haoyue Wang | ... | Zhaoming Ge
  • Special Issue
  • - Volume 2021
  • - Article ID 5431985
  • - Research Article

Expression of lncRNA-ANRIL before and after Treatment and Its Predictive Value for Short-Term Survival in Patients with Coronary Heart Disease

Jinhui Sun | Shi Qiu
  • Special Issue
  • - Volume 2021
  • - Article ID 5262000
  • - Research Article

Cystic Fibrosis: Systems Biology Analysis from Homozygous p.Phe508del Variant Patients’ Samples Reveals Perturbations in Tissue-Specific Pathways

Joice de Faria Poloni | Thaiane Rispoli | ... | José Eduardo Vargas
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.