Despite continued research efforts and expense, cancer remains an aggressive killer. It is one of the leading causes of death worldwide, representing one of the most significant healthcare issues for the human race. Over the last decade, novel synthetic anticancer agents have not been succeeded as presumed in current clinical use. Cancer comprises a group of various diseases and involves uncontrolled multiplication and division of abnormal cells, which can form malignant growths and divert signaling pathways. Cancer cells lose many of the regulatory functions that non-cancerous cells exhibit and become susceptible to chemotherapeutic drugs that are not devoid of their intrinsic side effects. Toxicities such as myelotoxicity, cardiotoxicity, genotoxicity, pulmonary toxicity, cutaneous toxicity, and vasospastic are the major side-effects for common anticancer drugs such as 5-fluorouracil, doxorubicin, and bleomycin are well documented. There is, therefore, a need to develop new, effective, safer, and more affordable anticancer drugs from alternative sources.

Plant products as a replacement for synthetic chemopreventive agents may provide a valuable approach for developing novel chemical entities to thwart cancer progression through the potential of bioactive plant secondary metabolites, many of which—such as vinblastine, vincristine, taxol, and camptothecin—have already been highlighted as having potential antitumor properties. There is also increasing evidence for plant-derived compounds' potential to act as inhibitors of various stages of tumorigenesis and associated inflammatory processes, underlining the importance of these products in cancer prevention. In addition to this, phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target locations with multiple scenarios/outcomes. Therefore, research into plant products may contribute to the development of effective and novel alternative therapeutics in the search for less toxic, eco-friendly, low-cost, fast, and cancer treatment drugs.

This Special Issue aims to collect original research and review articles regarding research into plant-derived products in cancer prevention.

Potential topics include but are not limited to the following:

• Natural products to prevent drug resistance in cancer chemotherapy
• Synergistic effects of natural products and immunotherapy in cancer therapy
• The mechanisms of natural compounds targeting cancer stem cells
• Targeting non-coding RNA by natural products for cancer therapy
• Prospects and paradigms of plant-based products mediated cancer treatment
• Biomarkers targeted for plant-derived anticancer drug development
• Cell-line studies in developing cancer treatments
• Functional foods for suppressing cancer cells
• Proteomics in cancer treatment