BioMed Research International

Plant-Derived Anticancer Agents as an Option for Cancer Treatment 2021


Publishing date
01 Apr 2022
Status
Closed
Submission deadline
19 Nov 2021

Lead Editor

1University of Dhaka, Dhaka, Bangladesh

2University of Khulna, Khulna, Bangladesh

3University of California Los Angeles , Los Angeles, USA

4Institute of Cancer and Basic Medicine, Chinese Academy of Sciences, Hangzhou, China

This issue is now closed for submissions.
More articles will be published in the near future.

Plant-Derived Anticancer Agents as an Option for Cancer Treatment 2021

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Despite continued research efforts and expense, cancer remains an aggressive killer. It is one of the leading causes of death worldwide, representing one of the most significant healthcare issues for the human race. Over the last decade, novel synthetic anticancer agents have not been succeeded as presumed in current clinical use. Cancer comprises a group of various diseases and involves uncontrolled multiplication and division of abnormal cells, which can form malignant growths and divert signaling pathways. Cancer cells lose many of the regulatory functions that non-cancerous cells exhibit and become susceptible to chemotherapeutic drugs that are not devoid of their intrinsic side effects. Toxicities such as myelotoxicity, cardiotoxicity, genotoxicity, pulmonary toxicity, cutaneous toxicity, and vasospastic are the major side-effects for common anticancer drugs such as 5-fluorouracil, doxorubicin, and bleomycin are well documented. There is, therefore, a need to develop new, effective, safer, and more affordable anticancer drugs from alternative sources.

Plant products as a replacement for synthetic chemopreventive agents may provide a valuable approach for developing novel chemical entities to thwart cancer progression through the potential of bioactive plant secondary metabolites, many of which—such as vinblastine, vincristine, taxol, and camptothecin—have already been highlighted as having potential antitumor properties. There is also increasing evidence for plant-derived compounds' potential to act as inhibitors of various stages of tumorigenesis and associated inflammatory processes, underlining the importance of these products in cancer prevention. In addition to this, phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target locations with multiple scenarios/outcomes. Therefore, research into plant products may contribute to the development of effective and novel alternative therapeutics in the search for less toxic, eco-friendly, low-cost, fast, and cancer treatment drugs.

This Special Issue aims to collect original research and review articles regarding research into plant-derived products in cancer prevention.

Potential topics include but are not limited to the following:

  • Natural products to prevent drug resistance in cancer chemotherapy
  • Synergistic effects of natural products and immunotherapy in cancer therapy
  • The mechanisms of natural compounds targeting cancer stem cells
  • Targeting non-coding RNA by natural products for cancer therapy
  • Prospects and paradigms of plant-based products mediated cancer treatment
  • Biomarkers targeted for plant-derived anticancer drug development
  • Cell-line studies in developing cancer treatments
  • Functional foods for suppressing cancer cells
  • Proteomics in cancer treatment

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 3647900
  • - Research Article

SH003 and Docetaxel Show Synergistic Anticancer Effects by Inhibiting EGFR Activation in Triple-Negative Breast Cancer

Yu-Jeong Choi | Kangwook Lee | ... | Seong-Gyu Ko
  • Special Issue
  • - Volume 2022
  • - Article ID 2277417
  • - Research Article

Antiinflammatory and Anticancer Properties of Grewia asiatica Crude Extracts and Fractions: A Bioassay-Guided Approach

Muhammad Qamar | Saeed Akhtar | ... | Tariq Ismail
  • Special Issue
  • - Volume 2022
  • - Article ID 5425485
  • - Review Article

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Arif Jamal Siddiqui | Sadaf Jahan | ... | Mohd Adnan
  • Special Issue
  • - Volume 2022
  • - Article ID 5792830
  • - Research Article

Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line

Khushboo Shahbaz | Jawaad Ahmed Asif | ... | Mohammad Khursheed Alam
  • Special Issue
  • - Volume 2022
  • - Article ID 1589877
  • - Review Article

Traditional and Phytochemical Bases of Herbs, Shrubs, Climbers, and Trees from Ethiopia for Their Anticancer Response

Limenew Abate | Mesfin Getachew Tadesse | ... | Rakesh Kumar Bachheti
  • Special Issue
  • - Volume 2022
  • - Article ID 3549061
  • - Research Article

Propylene Glycol Caprylate-Based Nanoemulsion Formulation of Plumbagin: Development and Characterization of Anticancer Activity

Adrian Chrastina | John Welsh | ... | Veronique T. Baron
  • Special Issue
  • - Volume 2021
  • - Article ID 9026731
  • - Research Article

Hepatoprotective Screening of Seriphidium kurramense (Qazilb.) Y.R. Ling

Maroof Ali | Hidayat Hussain | ... | Javad Sharifi-Rad
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.