BioMed Research International

Propionibacterium Acnes in Human Health and Disease


Publishing date
31 May 2013
Status
Published
Submission deadline
11 Jan 2013

Lead Editor

1Centre for Infection & Immunity, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, BT7 9BL, UK

2Department of Human Pathology, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

3School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK

4Department of Dermatology, Harrogate and District NHS Foundation, Harrogate, UK


Propionibacterium Acnes in Human Health and Disease

Description

Propionibacterium acnes are a widespread opportunistic pathogen that forms part of the microbiota of human skin and mucous membranes. This anaerobic bacterium has had a long association with the common inflammatory skin condition acne vulgaris, and it is also a recognised cause of ophthalmic, dental, and indwelling medical device-related infections, and a possible cause of various chronic human conditions including sarcoidosis, SAPHO syndrome, and prostate cancer. In stark contrast to its role as a pathogen, the powerful adjuvant properties of P. acnes have long been investigated for their ability to stimulate protective host immune responses against various human cancers and more generally against Th-2-mediated diseases. Within the last decade, molecular phylogenetic and genetic population studies have identified distinct phylogroups and lineages that appear associated with disease or maintaining health. This combined with the large amount of genomic data resulting from the human microbiome project and other sequencing programs now provides a sound evidential basis for hypothesis-driven research into the exact role of this organism in human disease, and the possibility of developing vaccines and other novel therapeutic treatments for P. acnes conditions.

The aim of this special issue is to provide a description of recent developments and advances in different areas of P. acnes research, and thus to provide a framework for discussion and the identification of key issues that need to be addressed in future studies. We are especially interested in original research articles, as well as reviews, that describe host-pathogen interactions, mechanisms of virulence, whole-genome studies, and vaccine development. Manuscripts that describe the role of P. acnes in different disease processes, antibiotic susceptibility, phylogenetic and population genetic studies, molecular genetic systems, and P. acnes bacteriophages would also be welcome. Potential topics include, but are not limited to:

  • Culture, cellular physiology, and phenotype
  • Host-pathogen interactions and immune responses
  • Putative colonisation factors and determinants of niche specificity
  • Putative determinants of virulence
  • Comparative genomics
  • Role in infection and chronic human disease
  • Antibiotic susceptibility
  • Molecular phylogenetics and epidemiology
  • Genetic systems
  • Animal and other models
  • P. acnes vaccines
  • P. acnes bacteriophages: basic biology and potential therapeutic applications

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/microbiology/pa/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 493564
  • - Editorial

Propionibacterium acnes in Human Health and Disease

Andrew McDowell | Sheila Patrick | ... | Anne Eady
  • Special Issue
  • - Volume 2013
  • - Article ID 804391
  • - Review Article

Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections

María Eugenia Portillo | Stéphane Corvec | ... | Andrej Trampuz
  • Special Issue
  • - Volume 2013
  • - Article ID 530382
  • - Research Article

Genotypic and Antimicrobial Characterisation of Propionibacterium acnes Isolates from Surgically Excised Lumbar Disc Herniations

Jess Rollason | Andrew McDowell | ... | Peter Lambert
  • Special Issue
  • - Volume 2013
  • - Article ID 254940
  • - Research Article

Microbial Biofilms and Breast Tissue Expanders

Melissa J. Karau | Kerryl E. Greenwood-Quaintance | ... | Robin Patel
  • Special Issue
  • - Volume 2013
  • - Article ID 151797
  • - Research Article

Correlation between Phylogroups and Intracellular Proteomes of Propionibacterium acnes and Differences in the Protein Expression Profiles between Anaerobically and Aerobically Grown Cells

Itaru Dekio | Renata Culak | ... | Haroun N. Shah
  • Special Issue
  • - Volume 2013
  • - Article ID 935289
  • - Review Article

Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes

Yoshinobu Eishi
  • Special Issue
  • - Volume 2013
  • - Article ID 603046
  • - Research Article

Deciphering the Intracellular Fate of Propionibacterium acnes in Macrophages

Natalie Fischer | Tim N. Mak | ... | Holger Brüggemann
  • Special Issue
  • - Volume 2013
  • - Article ID 679680
  • - Review Article

A Honey Trap for the Treatment of Acne: Manipulating the Follicular Microenvironment to Control Propionibacterium acnes

E. Anne Eady | Alison M. Layton | Jonathan H. Cove
  • Special Issue
  • - Volume 2013
  • - Article ID 918320
  • - Research Article

Analysis of Complete Genomes of Propionibacterium acnes Reveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain

Gabriela Kasimatis | Sorel Fitz-Gibbon | ... | Huiying Li
  • Special Issue
  • - Volume 2013
  • - Article ID 705741
  • - Review Article

Bacteriophages Infecting Propionibacterium acnes

Holger Brüggemann | Rolf Lood
BioMed Research International
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Acceptance rate31%
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CiteScore3.600
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