Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 4

Research Article

Microarray Analysis of mRNA and MicroRNA Expression Profile Reveals the Role of β-Sitosterol-D-glucoside in the Proliferation of Neural Stem Cell

Table 4

Upregulation genes.

GO ID Term valueGenes

GO:0000087M phase of the cell cycle AURKB; CCNF; KIF2C; BUB1B; CDCA3; IGF1; CENPF; DLGAP5; CDC20; SPAG5; MAD2L1; TRAF4AF1; NUSAP1; ESPL1; CCNB1; PLK1; PTTG1
GO:0000278Mitotic cell cycle SPAG5; MAD2L1; TRAF4AF1; NUSAP1; ESPL1; CDKN1B; CENPF; DLGAP5; CENPA; NDC80; CCNB1; PTTG1; CDC20; AURKB; CCNF;
GO:0000280Nuclear division SPAG5; MAD2L1; TRAF4AF1; NUSAP1; ESPL1; CCNB1; PLK1; PTTG1; CDC20; AURKB; CCNF; KIF2C; BUB1B; CDCA3; IGF1
GO:0007059Chromosome segregation SPAG5; MAD2L1; TRAF4AF1; NUSAP1; ESPL1; CCNB1; NDC80; PTTG1; CENPF; KIF2C; TOP2A
GO:0048285Organelle fission SPAG5; MAD2L1; TRAF4AF1; NUSAP1; ESPL1; CCNB1; CDCA3; PLK1; PTTG1; CDC20; AURKB; CCNF; KIF2C; BUB1B; IGF1
GO:0000226Microtubule cytoskeleton organization CENPA; NDC80; ESPL1; PLK1; KIF20A; KIF2C; SPAG5; TEKT1;
TRAF4AF1; CCNF; TACC3; CDKN1B; NUSAP1; CCNB1; AURKB
GO:0048545Response to steroid hormone stimulus CAR9; GBA; A2M; HP; IGF1; ADM; and so forth, a total of 22 genes
GO:0051301Cell division NUSAP1; PLK1; AURKB; KIF20A; NUMBL; TOP2A; TXNIP; CCNB2; CCNB1; PTTG1; CDC20; CCNF; KIF2C; BUB1B; CDCA3; TRAF4AF1
GO:0008283Cell proliferation CDC20; AURKB; CCNB1; PTTG1; IGF1; and so forth, a total of 39 genes
GO:0019932Second messenger-mediated signaling CALCA; ADORA2A; GRM3; EDNRB; GRM5; CXCR4; TOX3; RASD1; ADM; PDE7B; CDH13; IGF1; LMCD1; MT1A
GO:0009605Response to external stimulus A2M; LBP; CCNB1; ENPP2; CKLF; IGF1; and so forth, a total of 35 genes
GO:0009719Response to endogenous stimulus ADORA2A; IGF1; SPP1; A2M; and so forth, a total of 32 genes
GO:0008608Attachment of spindle microtubules to kinetochores CCNB1; SPAG5; TRAF4AF1; NDC80
GO:0009056Catabolism TOP2A; FBXO32; MANBA; IGF1; CDC20; and so forth, totle 41 genes
GO:0007051Spindle organization ESPL1; NDC80; TACC3; CCNB1; AURKB; SPAG5; TRAF4AF1
GO:0051313Attachment of spindle microtubules to chromosomes NDC80; CCNB1; SPAG5; TRAF4AF1
GO:0009725Response to hormone stimulus IGF1; LOX; SPP1; A2M; HP; ALPL; and so forth, a total of 27 genes
GO:0010941Regulation of cell death AURKB; IGF1; ADORA2A; and so forth, a total of 32 genes
GO:0043470Regulation of carbohydrate catabolism PFKFB3; DDIT4; IER3; IGF1
GO:0048016Inositol phosphate-mediated signaling EDNRB; GRM5; CALCA; IGF1; LMCD1

Upregulation genes obtained from the mRNA expression profiling were listed in Table 4. The upregulation genes were mostly involved in the mitotic cell cycle, enhancing cell proliferation. value, the significance testing value of the GO ID, results from the top GO of a bioconductor.

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