Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 5

Research Article

Microarray Analysis of mRNA and MicroRNA Expression Profile Reveals the Role of β-Sitosterol-D-glucoside in the Proliferation of Neural Stem Cell

Table 5

Downregulation genes.

GO IDTerm valueGenes

GO:0030154Cell differentiation FOXC2; IGF2; JAG1; SEMA3C; HMGA2; and so forth, a total of 38 genes
GO:0006950Response to stress PENK; BDNF; CRYAB; TRH; PLAU; MMP3; and so forth, a total of 32 genes
GO:2000736Regulation of stem cell differentiation HMGA2; JAG1; HES1
GO:0032103Positive regulation of response to external stimulus NPY; IL1RL1; SCG2; TNFSF11; CD74; THBS4
GO:0048710Regulation of astrocyte differentiation HES1; CLCF1; HMGA2
GO:0045597Positive regulation of cell differentiation TGFB1I1; CD74; FRZB; JAG1; BDNF; MAP1B; IFI204; TNFSF11; TNFRSF12A; HES1; CLCF1
GO:0048584Positive regulation of response to stimulus CD74; TNFSF11; TGFB1I1; CDKN1C; GPC3; HES1; NPY; CLCF1; IGF2; JAG1; PRRX2; IL1RL1; SCG2; THBS4; HMGA2; TNFRSF12A
GO:0000904Cell morphogenesis involved in differentiation HMGA2; MAP1B; BDNF; TGFB1I1; CHST3; FOXC2; TNFRSF12A; HES1; XYLT1; NPTX1
GO:0050920Regulation of chemotaxis SCG2; CD74; THBS4; EFNB2
GO:0030182Neuron differentiation MAP1B; BDNF; CHST3; NPY; MFRP; JAG1; HES1; CDKN1C; TNFRSF12A; HCN1; XYLT1; THBS4; NPTX1; BYSL
GO:0060326Cell chemotaxis TNFSF11; SCG2; CD74; THBS4
GO:0090398Cellular senescence HMGA2; RGD1305645
GO:0016477Cell migration SEMA3C; EFNB2; TNFSF11; TNFRSF12A; PLAU; MMP3; UNC5C; SCG2; THBS4; CD74; HES1
GO:0016126Sterol biosynthesis HMGCS2; HSD17B7
GO:0033554Cellular response to stress HMGA2; TNFSF11; MAP1B; CHST3; XYLT1; DHX9

Downregulation genes obtained from the mRNA expression profiling were listed in Table 5. The downregulation genes were mostly involved in differentiation and the regulation of differentiation, indicating that cell differentiation was inhibited, and accordingly, more possibility of cell proliferation was afforded. value, the significance testing value of the GO ID, results from the top GO of a bioconductor.

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