Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 5 / Research Article
Microarray Analysis of mRNA and MicroRNA Expression Profile Reveals the Role of β -Sitosterol-D-glucoside in the Proliferation of Neural Stem Cell Table 5 Downregulation genes.
GO ID Term
valueGenes GO:0030154 Cell differentiation
FOXC2; IGF2; JAG1; SEMA3C; HMGA2; and so forth, a total of 38 genes GO:0006950 Response to stress
PENK; BDNF; CRYAB; TRH; PLAU; MMP3; and so forth, a total of 32 genes GO:2000736 Regulation of stem cell differentiation
HMGA2; JAG1; HES1 GO:0032103 Positive regulation of response to external stimulus
NPY; IL1RL1; SCG2; TNFSF11; CD74; THBS4 GO:0048710 Regulation of astrocyte differentiation
HES1; CLCF1; HMGA2 GO:0045597 Positive regulation of cell differentiation
TGFB1I1; CD74; FRZB; JAG1; BDNF; MAP1B; IFI204; TNFSF11; TNFRSF12A; HES1; CLCF1 GO:0048584 Positive regulation of response to stimulus
CD74; TNFSF11; TGFB1I1; CDKN1C; GPC3; HES1; NPY; CLCF1; IGF2; JAG1; PRRX2; IL1RL1; SCG2; THBS4; HMGA2; TNFRSF12A GO:0000904 Cell morphogenesis involved in differentiation
HMGA2; MAP1B; BDNF; TGFB1I1; CHST3; FOXC2; TNFRSF12A; HES1; XYLT1; NPTX1 GO:0050920 Regulation of chemotaxis
SCG2; CD74; THBS4; EFNB2 GO:0030182 Neuron differentiation
MAP1B; BDNF; CHST3; NPY; MFRP; JAG1; HES1; CDKN1C; TNFRSF12A; HCN1; XYLT1; THBS4; NPTX1; BYSL GO:0060326 Cell chemotaxis
TNFSF11; SCG2; CD74; THBS4 GO:0090398 Cellular senescence
HMGA2; RGD1305645 GO:0016477 Cell migration
SEMA3C; EFNB2; TNFSF11; TNFRSF12A; PLAU; MMP3; UNC5C; SCG2; THBS4; CD74; HES1 GO:0016126 Sterol biosynthesis
HMGCS2; HSD17B7 GO:0033554 Cellular response to stress
HMGA2; TNFSF11; MAP1B; CHST3; XYLT1; DHX9
Downregulation genes obtained from the mRNA expression profiling were listed in Table 5 . The downregulation genes were mostly involved in differentiation and the regulation of differentiation, indicating that cell differentiation was inhibited, and accordingly, more possibility of cell proliferation was afforded.
value, the significance testing value of the GO ID, results from the top GO of a bioconductor.