Review Article

Large Dosage of Chishao in Formulae for Cholestatic Hepatitis: A Systematic Review and Meta-Analysis

Table 2

Intervention and outcome measures of included studies.

Study IDInterventionDuration/followup Adverse events Outcome measures
Trials group
(large dose Chishao formulae)
Control group

Tang et al. 2013 [14]Yin Chen Xiao Dan decoction
(Chishao 30 g) + Vitamin C + glucuronolactone + diammonium glycyrrhizinate Injection
Vitamin C + glucuronolactone + diammonium glycyrrhizinate injection30 days/NRNOTotal efficacy rate

Chen and Tu 2013 [15]Yin Chen Hao decoction jia wei
(Chishao 60 g) + sparagin + diammonium glycyrrhizinate + vitamin C
sparagin + diammonium glycyrrhizinate + vitamin CNRNRTotal efficacy rate, ALT, TBIL, -GT

Wu 2012 [16]Huo Xue Qing Dan decoction
(Chishao 30 g)
ademetionine injection2 months/NRNRTotal efficacy rate, ALT, AST, TBIL, DBIL

Xu et al. 2011 [17]Chishao relevant formulae
(Chishao 100 g) + essential treatment
Essential treatmentHospitalization time/NRNRTotal efficacy rate, ALB, AST, TBIL, PT

Zhu 2010 [18]Chishao relevant formulae
(Chishao 30 g–80 g) + diammonium glycyrrhizinate + vitamin K1 + sparagin + ademetionine or UDCA
Diammonium glycyrrhizinate + vitamin K1 + sparagin + ademetionine or UDCA1-2 months/NRNOTotal efficacy rate, ALT, TBIL, DBIL

He et al. 2008 [19]Chishao relevant formulae (Chishao 60 g) + diammonium glycyrrhizinate Injection + alprostadil injection + UDCA + vitamin C and vitamin BCOdiammonium glycyrrhizinate injection + alprostadil injection + UDCA + vitamin C and vitamin BCO4 weeks/NRNRTotal efficacy rate, ALT, AST, TBIL, DBIL, TBA, CGT, ALP

Xie et al. 2008 [20]Chishao Tui Huang decoction (60–100 g) + diammonium glycyrrhizinatediammonium glycyrrhizinate8 weeks/NRNRTotal efficacy rate

Shu 2007 [21]Wen Li Huo Xue decoction
(Chishao 25 g) + silymarine + Adenosine disodiu injection
Galle Donau + silymarine + adenosine disodiu injection2 months/1-2 monthsNOTotal efficacy rate, ALT, TBIL, GGT, ALP

Li 2006 [22]Jian Pi Li Dan decoction (Chishao 25 g) + vitamin K1 + vitamin BCO + glucuronolactoneDiammonium glycyrrhizinate injection + UDCA + vitamin K1 + vitamin BCO + Glucuronolactone40 days/3 monthsT: 2 Cases/C: 4 Cases with light digestive tract side effect.Total efficacy rate, TBIL, ALT, TBA, ALP

He et al. 2003 [23]Chi Dan Tui Huang granuleGalle Donau8 weeks/2 weeks–6 monthsT: 2 Cases/C: 4 Cases with light digestive tract side effect.Total efficacy rate, ALT, AST

He* et al. 2003 [24]Chi Dan Tui Huang granuleGalle Donau8 weeks/2 weeks–6 monthsT: 13 Cases/C: 3 Cases with light digestive tract side effect.Total efficacy rate, TBIL

“∗” in Table 1 and Table 2 refers to another study different from the study of the same name and year’