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International Journal of Alzheimer’s Disease
Volume 2010, Article ID 864625, 13 pages
Research Article

Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice

1Biologics Consulting Group, Inc., 400 N. Washington Street, Suite 100, Alexandria, VA 22314, USA
2Department of Medicine, Nursing, and Dentistry, University of Dundee, Nethergate, Dundee DD1 4HN, UK
3Metabolon Inc., 800 Capitola Drive, Suite 1, Durham, NC 27713-4385, USA
4Bayer Cropscience, 3500 Paramount Parkway Morrisville, NC 27560-7218, USA
5Pfizer, 558 Eastern Point Road Groton, CT 06340-5196, USA
6Proteostasis Therapeutics, 200 Technology Square, Suite 402, Boston, MA 02139, USA
7Department of Neuroscience, Duke University, Durham, NC 27708, USA
8Pfizer, Translational Medicine Research Collaboration, Dundee DD1 9SY, UK

Received 24 May 2010; Revised 23 August 2010; Accepted 3 September 2010

Academic Editor: Gemma Casadesus

Copyright © 2010 Orest Hurko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Thea Hammerschmidt, Markus P. Kummer, Dick Terwel, Ana Martinez, Ali Gorji, Hans-Christian Pape, Karen S. Rommelfanger, Jason P. Schroeder, Monika Stoll, Joachim Schultze, David Weinshenker, and Michael T. Heneka, “Selective Loss of Noradrenaline Exacerbates Early Cognitive Dysfunction and Synaptic Deficits in APP/PS1 Mice,” Biological Psychiatry, vol. 73, no. 5, pp. 454–463, 2013. View at PublisherView at Google Scholar
  • Markus P. Kummer, Thea Hammerschmidt, Ana Martinez, Dick Terwel, Gregor Eichele, Anika Witten, Stefanie Figura, Monika Stoll, Stephanie Schwartz, Hans-Christian Pape, Joachim L. Schultze, David Weinshenker, and Michael T. Heneka, “Ear2 Deletion Causes Early Memory and Learning Deficits in APP/PS1 Mice,” Journal of Neuroscience, vol. 34, no. 26, pp. 8845–8854, 2014. View at PublisherView at Google Scholar
  • Jun Peng, Kevin Guo, Jianguo Xia, Jianjun Zhou, Jing Yang, David Westaway, David S. Wishart, and Liang Li, “Development of Isotope Labeling Liquid Chromatography Mass Spectrometry for Mouse Urine Metabolomics: Quantitative Metabolomic Study of Transgenic Mice Related to Alzheimer's Disease,” Journal of Proteome Research, vol. 13, no. 10, pp. 4457–4469, 2014. View at PublisherView at Google Scholar
  • Trevor Archer, “Noradrenergic–Dopaminergic Interactions Due to DSP-4–MPTP Neurotoxin Treatments: Iron Connection,” Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology, vol. 29, pp. 73–86, 2015. View at PublisherView at Google Scholar
  • Douglas L. Feinstein, Sergey Kalinin, and David Braun, “Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system,” Journal of Neurochemistry, 2016. View at PublisherView at Google Scholar
  • Ashok Kumar, Brittney Yegla, and Thomas C. Foster, “Redox Signaling in Neurotransmission and Cognition During Aging,” Antioxidants & Redox Signaling, 2017. View at PublisherView at Google Scholar
  • Douglas L. Feinstein, and Michael T. Henekapp. 301–311, 2017. View at PublisherView at Google Scholar