Effect of Chronic Consumption of Sweeteners on Microbiota and Immunity in the Small Intestine of Young Mice
Table 4
Cytokine CD4+ T cell response from Peyer's patches and lamina propria of CD1 mice supplemented with sweeteners for 6 and 12 weeks.
CL
SUC
Splenda®
Svetia®
Mean±SD
Mean±SD
Mean±SD
Mean±SD
P value∗
(%)
(%)
(%)
(%)
6 weeks of treatment, Peyer’s patches
IL-6
4.59±0.064
2.77±0.08
3.52±0.069
2.47±0.106
0.001∗
IL-17A
1.15±0.08
2.94±0.074
3.87±0.058
3.33±0.074
0.001∗
12 weeks of treatment, Peyer’s patches
IL-6
6.16±0.08
8.29±0.053
11±0.176
8.38±0.053
0.001∗
IL-17A
1.71±0.08
4.46±0.235
5.04±0.053
5.32±0.074
0.001∗
6 weeks of treatment, Lamina propria
IL-6
9.39±0.08
10.11±0.053
16.01±0.176
11.94±0.053
0.001∗
IL-17A
3.85±0.074
7.41±0.074
7.89±0.058
11.15±0.074
0.001∗
12 weeks of treatment, Lamina propria
IL-6
6.16±0.08
8.29±0.053
11±0.176
8.38±0.053
0.001∗
IL-17A
3.36±0.074
12.25±0.074
12.04±0.058
10.17±0.08
0.001∗
The values represent the mean±SD of percentage of intracellular cytokines of Peyer’s patches and lamina propria in mice supplemented with sweeteners. Two-way ANOVA was performed to compare the differences between the groups. The differences were considered statistically significant with p <0.05 ∗.
