G1: 100 mg/kg G2: 200 mg/kg G3, 4, 5: 300 mg/kg G9: 0.5 ml of NS (0.9%), then 300 mg/kg
3 weeks
G3: 38 mmHg G4: 24 mmHg G5: 23 mmHg
N/A
(i) All types of celery extracts cause a reduction in SBP and increased HR in hypertensive groups but not the normotensive group (ii) Hexanic extract contains 3.7 to 4 more n-butylphthalide content than methanolic and aqueous-ethanolic extract, respectively
(i) Celery seed extract has endothelium-dependent vasorelaxant effects in rat’s aortic rings (ii) There are two possible relaxation mechanisms: inhibition of calcium influx into smooth muscle cells and activation of voltage-dependent potassium channels
Dose 12.5 mg/kg: 69.5% reduction in normotensive groups and 34.6% in hypertensive groups
Dose 12.5 mg/kg: 80% reduction in normotensive groups and 37.6% in hypertensive groups
(i) Hexanic extract contains more n-butylphthalide than aqueous-ethanolic extract (ii) Hexanic celery extract significantly reduces SBP, DBP, MABP, and HR in normotensive and hypertensive groups (iii) Involved mechanisms in celery’s hypotensive effect are vasodilation effect via blocking calcium channels and bradycardia induction (iv) Celery’s hexanic extract and nifedipine have a similar effect on BP but not HR
(i) There is a significant reduction in SBP in groups receiving fructose and celery extract in comparison with fructose group (ii) No significant HR alteration in any group
Quasiexperiment using the form of pretest and posttest control group design
No treatment
Celery juice
N/A
N/A
17.58
7.08
(i) Significant effect of celery juice on hypertension patients was found (ii) Celery juice has a strong tolerance to SBP and moderate closeness to DBP
(i) There is a significant decrease in both SBP and DBP after celery extract treatment (ii) Celery is considered safe for hypertension patients with positive effect on BG and lipid profile (iii) There is no change in HR in both control and intervention groups