Formulation Optimization and Evaluation of Probiotic Lactobacillus sporogenes-Loaded Sodium Alginate with Carboxymethyl Cellulose Mucoadhesive Beads Using Design Expert Software

Table 2

Summary of ANOVA for the response parameters in 3² factorial designs.

Source	Sum of squares	df	Mean square	value	value; Prob. > F	Significance
For entrapment efficiency (%)
Model	21.62	2	10.81	99.23	<0.0001	Significant
	19.05	1	19.05	174.83	<0.0001
	2.57	1	2.57	23.63	0.0028
Residual	0.65	6	0.11
Cor. total	22.27	8
For viability in SGF (log10 CFU)
Model	1.13	5	0.23	12.84	0.03	Significant
	0.06	1	0.06	3.53	0.16
	0.30	1	0.30	17.00	0.03
	0.05	1	0.05	3.08	0.18
	0.08	1	0.09	4.77	0.12
	0.34	1	0.34	19.40	0.02
Residual	0.05	3	0.018
Cor. total	1.18	8
For mucoadhesion (%)
Model	448.86	2	224.43	188.54	<0.0001	Significant
	42.14	1	42.14	35.40	0.0010
	406.73	1	406.73	341.68	<0.001
Residual	7.14	6	1.19
Cor. total	456.03	8