Formulation Optimization and Evaluation of Probiotic Lactobacillus sporogenes-Loaded Sodium Alginate with Carboxymethyl Cellulose Mucoadhesive Beads Using Design Expert Software

Table 3

Results of experiments for confirming optimization capability.

(a)

Code	Factor
	(%)	(%)
F-O	3.27	1.00

(b)

Response	Predicted value	Observed value	% error
= entrapment efficiency (%)	95.02	93.7 ± 1.97	1.39
= viability in SGF after 2 hr exposure (log CFU)	9.3	9.34 ± 0.3	−0.438
= mucoadhesion over 8 hr (%)	73.81	71.75 ± 1.38	3.60

Observed response values: mean ± S.D. ().
Error (%) = [difference between predicted value and actual value/predicted value] × 100.