Transcriptomic Profiling of Human Placental Trophoblasts in Response to Infection with Enterococcus faecalis

Table 2

DEGs associated with signal pathways assigned by KEGG pathway analysis.

No.	Term	Count	Genes
1	hsa04310:Wnt signaling pathway	18	CTBP1, CTBP2, TP53, CTNNB1, DVL1, MAP3K7, EP300, PSEN1, PRICKLE1, CSNK1E, JUN, PPP2CB, NFAT5, FRAT1, CAMK2B, NFATC4, PRKACB, NFATC1
2	hsa04010:MAPK signaling pathway	31	FGFR4, PDGFB, PDGFA, PPM1A, MKNK2, MAP4K1, PPM1B, NFKB2, MAP3K7, MAX, FOS, PAK2, PLA2G12A, NFATC4, PRKACB, TRAF6, MAP2K7, HSPA8, RASA2, EGFR, RELA, MAP2K4, TP53, ATF4, JUN, PDGFRB, MAPK7, GADD45B, CRK, PLA2G2D, GADD45A
3	hsa04662:B cell receptor signaling pathway	15	PTPN6, IFITM1, NFKBIE, RELA, NFKBIB, NFKBIA, FOS, CARD11, LILRB3, JUN, NFAT5, NFATC4, PIK3R3, PIK3R1, NFATC1
4	hsa04660:T cell receptor signaling pathway	18	PTPN6, NFKBIE, RELA, NFKBIB, NFKBIA, MAP3K7, FOS, NCK2, CARD11, PAK2, JUN, PAK4, NFAT5, NFATC4, PIK3R3, MAP2K7, PIK3R1, NFATC1
5	hsa04620:Toll-like receptor signaling pathway	13	CCL3, IL6, RELA, MAP2K4, TIRAP, NFKBIA, MAP3K7, FOS, JUN, PIK3R3, TRAF6, MAP2K7, PIK3R1
6	hsa04630:Jak-STAT signaling pathway	20	PTPN6, IL6, SOCS3, LEPR, LIFR, SOCS7, SOCS4, BCL2L1, STAT3, LEP, ZFP91, TSLP, STAT4, SPRY1, EP300, IL10RB, IL5RA, MPL, PIK3R3, PIK3R1
7	hsa04510:focal adhesion	25	PDGFB, XIAP, PDGFA, COL2A1, ITGB1, CTNNB1, MYL9, VCL, PTK2, PAK2, PAK4, COL6A2, PDGFC, PIK3R3, PIK3R1, EGFR, TNXA, BAD, VWF, JUN, ITGA7, VEGFA, PDGFRB, COL1A1, CRK
8	hsa04520:adherens junction	12	MAP3K7, EGFR, PTPN6, PVRL4, EP300, PVRL1, BAIAP2, PVRL2, CTNND1, WAS, CTNNB1, VCL
9	hsa04810:regulation of actin cytoskeleton	23	EGFR, FGFR4, PDGFB, LIMK2, PDGFA, BAIAP2, ITGB1, WAS, MYL9, TTLL3, VCL, PTK2, ARPC3, PAK2, GSN, CFL2, PAK4, ITGA7, PDGFRB, PDGFC, PIK3R3, CRK, PIK3R1
10	hsa05130:pathogenic Escherichia coli infection	9	NCK2, YWHAZ, KRT18, ARPC3, LOC399942, WAS, ITGB1, CTNNB1, TTLL3
11	hsa04115:p53 signaling pathway	10	CDKN1A, CDKN2A, ZMAT3, BAI1, RPRM, TP53, CHEK2, GADD45B, CCNG2, GADD45A
12	hsa04210:apoptosis	14	XIAP, AIFM1, RELA, TP53, NFKBIA, BAD, BCL2L1, IRAK3, CASP6, TNFSF10, IL1RAP, PRKACB, PIK3R3, PIK3R1
13	hsa04150:mTOR signaling pathway	8	CAB39L, EIF4E, TSC1, STK11, VEGFA, PIK3R3, PIK3R1, DDIT4