Review Article

Chemistry, Safety, and Challenges of the Use of Organic Acids and Their Derivative Salts in Meat Preservation

Table 4

Lethal dose by rat oral ingestion (LD50 rat), Acceptable Daily Intake (ADI), and application limits in meat of commonly used organic acids/salts.

Organic acid/saltLD50 rat, oral (mg/kgBW)ADI (mg/kgBW)Application limits in meat

Acetic acid3310UndefinedQuantum satis
Sodium acetate3530UndefinedGood manufacturing practice
Benzoic acid170051000 ppm
Sodium benzoate407051000 ppm
Citric acid3000UndefinedQuantum satis
Lactic acid3540UndefinedQuantum satis
Potassium lactate>2000UndefinedGood manufacturing practice
Propionic acid370Undefined2500 ppm
Tartaric acid750030Good manufacturing practice
Sorbic acid7360251000 ppm
Potassium sorbate2600251000 ppm

LD50 rat: lethal dose 50% for rat, dose required to kill 50% of tested rats; oral: oral ingestion; BW : body weight.