Review Article

Extraction of Flavonoids from Corn Silk and Biological Activities In Vitro

Table 3

Bioactivity and extraction method of flavonoids or flavone glycosides from corn silk.

BioactivityExtraction methodResultsProducing areaReferences

Antioxidant activityEthanol-water extractionThe percentage of DPPH radical scavenged by CS extract was 92.6 at a concentration of 1.6 mg/ml−1Iran[54]
Three separate solvents (ethyl acetate, ethanol, and water)The ABTS inhibition of immature and mature silks was ranged from 13.4% to 35% and 15.56% to 44.36%, respectivelyMalaysia[16]
Ultrasound-assisted extractionFRAP value of total flavonoids extracted from corn silk was 467.59 μmol/LChina[34]

Antibacterial activityThe petroleum ether (PECS), chloroform (CECS), and methanol (MECS) extractionsPECS, MECS, and flavonoids were active against eleven bacteria out of twelve bacteria. CECS was active only against five bacteriaMalaysia[46]
Ethanol, chloroform, and methanol extractionsEthanol extract showed significant antimicrobial activity against both Gram-positive bacteria (13.17 to 9.45 mg/ml) and Gram-negative bacteria (12.36 to 8.15 mg/ml) bacteriaBangladesh[55]
Aqueous extractionThe antimicrobial activity against Staphylococcus aureus and Bacillus subtilis is 500 mg/ml and 62.5 mg/ml. The minimum inhibitory concentration to Candida albicans is 125 mg/mlChina[27]

Antidiabetic activityEthanol extractionTreatment with 300 mg/kg or 500 mg/kg of corn silk flavonoids significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic miceChina[15]

Antifatigue activityHot ethanol continuous extractionSwimming exercise results indicated that corn silk flavonoids had antifatigue activity of mice by inhibiting the production of blood lactic acidChina[17]
Hot ethanol continuous extractionCorn silk flavonoids could elevate the exercise tolerance of mice and provide protection against oxidative stress induced by exhaustive exercise in miceChina[14]