The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population
Table 5
The association between alleles or haplotypes and severity types in hemorrhagic fever with renal syndrome.
Allele or haplotype
Fold of frequency
P
Pc
OR (95% CI)
HLA-B*46
mild/moderate versus control
0.59
0.336
0.55 (0.16–1.88)
severe/critical versus control
2.52
<0.001
<0.001
3.44 (1.70–6.93)
mild/moderate versus severe/critical
0.24
0.004
0.018
0.16 (0.04–0.62)
HLA-DRB1*09
mild/moderate versus control
1.51
0.136
1.78 (0.83–3.85)
severe/critical versus control
1.87
0.006
0.06
2.52 (1.29–4.93)
mild/moderate versus severe/critical
0.81
0.482
0.71 (0.27–1.85)
HLA-DRB1*12
mild/moderate versus control
0.78
0.498
0.73 (0.29–1.83)
severe/critical versus control
0.31
0.017
0.17
0.26 (0.08–0.85)
mild/moderate versus severe/critical
2.50
0.151
2.85 (0.65–12.43)
HLA-B*46-DRB1*09
mild/moderate versus control
0.82
0.781
0.81 (0.18–3.57)
severe/critical versus control
2.87
0.002
—
3.41 (1.48–7.86)
mild/moderate versus severe/critical
0.29
0.064
0.24 (0.05–1.19)
HLA-B*51-DRB1*09
mild/moderate versus control
1.99
0.512
2.02 (0.24–17.35)
severe/critical versus control
4.63
0.016
—
4.92 (1.18–20.48)
mild/moderate versus severe/critical
0.43
0.439
0.41 (0.04–4.16)
The alleles and haplotypes were selected for their P value of frequency < 0.05 in Tables 3 and 4. P value derived from Pearson Chi-square test; OR: odds ratio; CI: confidence interval; numbers in bold indicate a significant P value.
