Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats
Figure 6
Cytospins of BAL cells recovered from rats on days 1 (a), 7 (b), 28 (c), and 91 days (d) after intratracheal instillation with 250 μg of Si NW, demonstrating resolution of inflammatory response over time. 1 day after instillation of Si NW, there is a strong inflammatory response with significant neutrophil influx, as well as eosinophil influx (red arrows). AMs containing the Si NW (shiny birefringent material) indicated by the green arrows decreased over time. Additionally, reduction of Si NW burden in AMs over time was observed. See Table 3 and Figure 10 regarding Si NW clearance from the lung.
