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Mediators of Inflammation
Volume 2013 (2013), Article ID 864319, 23 pages
http://dx.doi.org/10.1155/2013/864319
Review Article

Pharmacogenetics of Chronic Pain and Its Treatment

Institute of Pharmacology, First Faculty of Medicine, Charles University Prague, Albertov 4, 12800 Prague, Czech Republic

Received 30 January 2013; Accepted 12 April 2013

Academic Editor: Metoda Lipnik-Stangelj

Copyright © 2013 Svatopluk Světlík et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers.