Minimally Invasive Surgery

Minimally Invasive Surgery / 2014 / Article
!A Corrigendum for this article has been published. To view the article details, please click the ‘Corrigendum’ tab above.

Review Article | Open Access

Volume 2014 |Article ID 384706 |

Mehmet Ali Yagci, Cuneyt Kayaalp, "Transvaginal Appendectomy: A Systematic Review", Minimally Invasive Surgery, vol. 2014, Article ID 384706, 8 pages, 2014.

Transvaginal Appendectomy: A Systematic Review

Academic Editor: Peng Hui Wang
Received26 Aug 2014
Accepted04 Dec 2014
Published29 Dec 2014


Background. Natural orifice transluminal endoscopic surgery (NOTES) is a new approach that allows minimal invasive surgery through the mouth, anus, or vagina. Objective. To summarize the recent clinical appraisal, feasibility, complications, and limitations of transvaginal appendectomy for humans and outline the techniques. Data Sources. PubMed/MEDLINE, Cochrane, Google-Scholar, EBSCO, and congress abstracts, were searched. Study Selection. All related reports were included, irrespective of age, region, race, obesity, comorbidities or history of previous surgery. No restrictions were made in terms of language, country or journal. Main Outcome Measures. Patient selection criteria, surgical techniques, and results. Results. There were total 112 transvaginal appendectomies. All the selected patients had uncomplicated appendicitis and there were no morbidly obese patients. There was no standard surgical technique for transvaginal appendectomy. Mean operating time was 53.3 minutes (25–130 minutes). Conversion and complication rates were 3.6% and 8.2%, respectively. Mean length of hospital stay was 1.9 days. Limitations. There are a limited number of comparative studies and an absence of randomized studies. Conclusions. For now, nonmorbidly obese females with noncomplicated appendicitis can be a candidate for transvaginal appendectomy. It may decrease postoperative pain and enable the return to normal life and work off time. More comparative studies including subgroups are necessary.

1. Introduction

Since its original description by Mc Burney in 1894, appendectomy has been one of the most common surgical procedures performed by surgeons. In the last decades, laparoscopic appendectomy was an increasingly accepted treatment method for acute appendicitis, particularly for obese or female patients [1]. Natural orifice transluminal endoscopic surgery (NOTES) is a new approach that allows for minimal invasive surgery through the natural orifices such as mouth, anus, or vagina. This technique aims to avoid any visible scars on the body surface. Less incision on the abdomen helps to reduce surgical pain, analgesic requirement, recovery time, hernia formation, intra-abdominal adhesion, and surgical site infection. However, NOTES has several disadvantages and limitations with the currently available instruments, including limited access and less familiar working angles and operative views. In the past few years, many centers have published their experiences with NOTES appendectomies in humans. This study aimed to summarize the recent clinical appraisals, feasibility, complications, and limitations of transvaginal appendectomy for humans and to outline techniques.

2. Material and Methods

Electronic searches in December 2013 of the PubMed/MEDLINE, Cochrane, Google Scholar, and EBSCOhost-Academic Search Complete, including CINAHL, used the key words [(vaginal OR transvaginal) AND (appendectomy OR appendectomies OR appendicectomy OR appendicectomies)]. All the studies including congress proceedings and abstracts that describe the clinical course of patients were accepted for the analysis. Two reviewers (Mehmet Ali Yagci and Cuneyt Kayaalp) assessed the list of titles and/or abstracts of the scanned articles at PubMed/MEDLINE and Cochrane using the key words in a function of [all fields]. If the articles met our inclusion criteria, full-text versions were obtained for assessment. If the articles were obviously irrelevant to the aim of this systematic review, they were excluded. Additional studies were also excluded due to their content (editorial letters, reviews, experimental studies, duplicated studies, technical notes not including patient data, and survey studies including questionnaires). After PubMed and Cochrane searches, we scanned the EBSCOhost-Academic Search Complete and Google Scholar databases with the same key words but using the [title] function. If any additional studies were found, they were added to the first search results. The unpublished, potentially relevant, trials at the registered trials database at were searched as well. The references of the selected relevant articles were cross checked to decrease the possibility of missing publications.

Transvaginal appendectomy was defined as a way of natural orifice translumenal endoscopic surgery for the appendix. Studies describing concomitant appendectomies during transvaginal hysterectomy were not considered for this systematic review. All the patients were included, irrespective of age, region, race, obesity, comorbidities, or history of previous surgery. No restrictions were made on language, country, or journal. In cases of disagreement during the study selection and analysis, the reviewers discussed the disagreement and a consensus was reached. Data for affiliation, number of the patients, age, clinical findings, inclusion and exclusion criteria, body mass index, history of previous abdominal surgery, trocar sites (pure or hybrid) and types, scope site and types (flexible or rigid), vaginal access and colpotomy closure techniques, intraoperative and postoperative complications, operating time, conversion to conventional laparoscopy or open surgery, postoperative pain, length of hospital stay, time off work, long term sexual function, and cosmetic satisfaction were recorded. A computer program including spreadsheet was used for records (Excel 2013, Microsoft Windows). If there were any missing data, we tried to contact the authors via e-mail.

Data were tabulated in tables, and column sums were created with the numbers or the means ± standard deviations, or the ranges of relevant parameters. When studies reported the median and range, we estimated the mean and standard deviation using the method described by Hozo et al. [2]. Basic calculations were used for the total numbers of the dichotomous outcomes and weighted means with ranges for the continuous outcomes. Chi-square test or the Fisher exact test (if expected values were less than 5) and Student’s -test were used for statistical analysis of both dichotomous and continuous variables (SPSS 13.0). A value <.05 was considered significant.

3. Results

A total of 154 articles were retrieved from the PubMed/MEDLINE database and no additional study was available in the Cochrane library. After the elimination of the 96 irrelevant studies, the remaining 58 were selected for full-text examination. Google Scholar, EBSCOhost-Academic Search Complete,, and reference cross-checking defined 26, 17, 6, and 2 studies, respectively (Figure 1). After the elimination of repetitive studies in several databases or sources, seven studies were added to the previously selected 58 articles. Studies including inadequate patient data, concomitant hysterectomy, experimental studies, and duplicated data were eliminated and finally 13 articles [315] were selected for the analysis (Figure 1). Two studies [10, 11] belonged to the same clinical series and their data were complementary (early and late results). As a result, we analyzed 12 clinical studies contained in 13 articles. Some studies had duplicated results [1622] and their latest or the most comprehensive versions were accepted for the analysis [6, 1013].

There were a total of 112 transvaginal appendectomies. Studies originated in Europe, North/South America, and Asia, and two of them included international multicenter data [6, 13]. Publications were generally (11/13) in English but one was in German [9], and one was in Japanese [14]. The patients’ ages were generally in the mid-twenties or mid-thirties; however, there was a large age range (18–74 years). Inclusion criteria of the studies for transvaginal appendectomy are summarized in Table 1. All the patients were in the American Society of Anesthesia (ASA) I-II scores. A diagnosis of complicated appendicitis (perforation, abscess, and mass) was usually an exclusion criterion. Morbidly obese patients (body mass index more than 35 kg/m2) were also excluded, and the mean body mass index of the patients in this systematic review was 23.2 kg/m2 (Table 2) [4, 79, 13, 14]. Previous abdominal or pelvic surgery was not an exclusion criterion in all studies and 11% of the patients had a history of abdominal or pelvic surgery [9, 15]. Most of the cases (96%) were of acute appendicitis, while others (4%) were chronic appendicitis or incidental appendectomies.

Parameters Zorron et al. [6] Pérez et al. [7]Roberts et al. [10]Jacobsen et al. [12]Noguera et al. [8]Albrecht et al. [9]Mofid et al. [15]



Disease severityMild symptoms and short duration of diseaseNo palpable mass 
No appendicular abscess
Not perforated at clinical and radiological evaluation<48 hours of the onset 
No abdominal abscess 
No abdominal mass 
No sepsis 
No diffuse peritonitis
NAUnclear abdominal discomfort in the sense of appendicitisNA

Previous surgeryNo history of hysterectomy 
Some centers avoided prior other abdominal surgeries
NANo abdominal or pelvic surgeryNANAPrevious abdominal or pelvic surgery was not a contraindicationPrevious abdominal or pelvic surgery was not a contraindication

Virginity or pregnancyNot virgin 
Not pregnant
Not virgin 
Not pregnant
Not pregnantNot pregnantNANANA


Gynecological pathologiesNo vaginal infection 
No endometriosis 
No obliterating adhesions in the pouch of Douglas
No gynecological infectionNANo history of ectopic pregnancy, PID, severe endometriosis, or perineal traumaNANANo known adhesions in the pelvis

OthersNANANot retrocecal at preoperative radiological evaluationNo immunosuppressive drug 
Not immunocompromised 
No blood thinner medication 
No platelet inhibitor drugs 
Normal coagulation tests
Previous delivery of at least one childNANo malignancy 
No previous pelvic radiotherapy

NA: not available, BMI: body mass index, ASA: American Society of Anesthesiology, and PID: pelvic inflammatory disease.

AuthorYearCountryNumberAge (mean)Appendectomy indicationBMIPrior surgery

Bernhardt et al. [3]2008Germany128Subacute NANo
Tabutsadze and Kipshidze [4]2009Georgia222, 28Acute22.2 & 23.5No
Shin et al. [5]2010Korea174Acute Not obeseNo
Zorron et al. [6]2010International37NAAcute NASome
Pérez et al. [7]2011Cuba829.6 (18–42)Acute <35NA
Noguera et al. [8]2011Spain4NAAcute (2), incidental (2)NANA
Roberts et al. [10]2012USA1831.3Acute23.7No
Albrecht et al. [9]2013Germany30 33.9Acute23.7Yes (5)
Jacobsen et al. [12] 2014USA3NAAcuteNANA
Arezzo et al. [13]2013International531.2 (23–42)Acute18.9 (18-19)NA
Wada et al. [14]2013Japan150Acute24.2No
Mofid et al. [15]2013Germany2NAChronicNAYes (1)

BMI: body mass index.

Mean operating time was 53.3 minutes and ranged from 25 to 130 minutes. There were nine complications reported in 109 cases (8.2%). Four of them were intraoperative complications: appendicular artery hemorrhage (: 3) and inability to sustain the pneumoperitoneum (: 1). Those cases required additional abdominal trocar access and were accepted as a conversion to conventional laparoscopy (3.6%), but no case required conversion to open surgery. Postoperative complications occurred in five patients and all were treated by nonsurgical methods (Table 3). Intra-abdominal abscess, urinary retention, urinary infection, and dyspareunia were treated by percutaneous drainage plus antibiotics, Foley catheter placement, antibiotics, and just waiting, respectively. Mean length of hospital stay was 1.9 days for all studies. The mean length of hospital stay was longer in the German series (3.4 days) because of their national health system, [3, 9], and the mean length of hospital stay was 1.25 days for the rest of the studies.

AuthorNumberOperating time (min) mean (range)Complications (number)Conversion to laparoscopy (number)Length of stay (mean and range)

Bernhardt et al. [3]1NANoNo3
Tabutsadze and Kipshidze [4]276 & 88NoNo1.25 & 1.5
Shin et al. [5]160NoNo3
Zorron et al. [6]3760.5 (90 for flexible)Appendicular artery hemorrhage (3)Appendicular artery hemorrhage (3)1.3
Pérez et al. [7]848.3 (37–75)NoNo1.1 (<1-2)
Noguera et al. [8]461NoNoNA
Roberts et al. [10]1844.4Intra-abdominal abscess (1)  
Urinary retention (1)  
Unable to sustain pneumoperitoneum (1)
Unable to sustain pneumoperitoneum (1)1.1
Albrecht et al. [9]3044.3Urinary infection (1)  
Dyspareunia (2)
Jacobsen et al. [12]371 (55–80)NANoNA
Arezzo et al. [13]5Rigid: 42.5 (40–45)  
Flexible: 70 (60–90)
NoNoRigid: 1.5 (1-2) 
Flexible: 1.3 (1-2)
Wada et al. [14]1130NoNo1
Mofid et al. [15]225 & 32NoNoNA

There was no standard surgical technique for transvaginal appendectomy (Figure 2). Some studies used only the transvaginal access, called a pure or totally transvaginal appendectomy. Others used an abdominal assistance (usually a 5 mm umbilical trocar) to the transvaginal access and are called a hybrid technique (Table 4). Pure transvaginal appendectomy was performed on only 22% of the cases and the remaining were hybrid procedures (78%). When we compared the operating time and the complications for both techniques, there were no differences. The operating times for pure [4, 10] and hybrid [5, 9, 1215] techniques were minutes and minutes, respectively (). Complication rates for pure [3, 4, 10] and hybrid [5, 79, 1215] techniques were 19.0% and 5.5%, respectively (). Another technical difference was related to the type of scope. Some authors used flexible endoscopes (20%) and others preferred rigid laparoscopes (80%). Operating times with flexible endoscopes [4, 5, 12, 13] and rigid laparoscopes [9, 10, 1315] were minutes and minutes, respectively (). Complication rates for using flexible [35, 8, 12, 13] and rigid [7, 9, 10, 1315] scopes were 0% and 11.4%, respectively ().

AuthorNumberVaginal trocarUmbilical assistance Working accessFlexible or rigid scope

Bernhardt et al. [3]1NoNo (pure)Endoscope channelFlexible
Tabutsadze and Kipshidze [4]2NANo (pure)Endoscope channelFlexible
Shin et al. [5]115 mm5 mm (hybrid)Endoscope channelFlexible
Zorron et al. [6]3710 or 12 mmNo (pure) or 5 mm (hybrid)NABoth
Pérez et al. [7]811 mm5 mm (hybrid)Laparoscope channelRigid
Noguera et al. [8]415 mm5 mm (hybrid)Endoscope channelFlexible
Roberts et al. [10]18SILS portNo (pure)TV SILS portRigid
Albrecht et al. [9]3012 mm5 mm (hybrid)TV 5 mm portRigid
Jacobsen et al. [12]315 mm5 mm (hybrid)Through TV 15 mm trocarFlexible
Arezzo et al. [13]512 mm5 mm (hybrid)NAFlexible (3), rigid (2)
Wada et al. [14]112 mm5 mm (hybrid)2.3 mm umbilical trocarRigid
Mofid et al. [15]25 and 10 mm 5 mm (hybrid)TV 5 mm trocarRigid

TV: transvaginal.

4. Discussion

Transvaginal appendectomy during vaginal hysterectomy was first described in 1949 [23] and, at the time, was performed by the gynecologists with the aim of incidental appendectomy [6, 23]. Those studies did not include the acute appendicitis cases and their primary objectives were the treatment of gynecological pathologies, not the appendix. In 2008, the first transvaginal appendectomy without vaginal hysterectomy was reported by Palanivelu and coworkers from India [22] and after a short period of time three more cases were reported one from Germany [3] and two from Georgia [4]. Interestingly, these first three separate reports of transvaginal appendectomies all described the totally transvaginal (pure) technique using only an endoscope [3, 4, 22]. In those cases, there was no abdominal trocar for assistance, nor was there any other transvaginal equipment except endoscopes. All the procedures were performed through the working channels of the endoscopes. Mesoappendixes were transected and the bases of the appendixes were secured with endoloops. Transection of the appendixes was done with scissors [3, 4] or snares [22] through the endoscopic channels. All the specimens were removed with the help of the endoscope and no extraction bags were used. Mean operating time was 95 minutes and ranged between 72 and 135 minutes. Palanivelu et al. reported that, before the first successful case, they experienced three prior conversions to conventional laparoscopic appendectomy due to technical difficulties with this pure endoscopic technique [22]. Bernhardt et al. used the same technique and reported that their case was not an acute appendicitis, but a recurring subacute appendicitis [3]. We can conclude that, despite its minimal invasiveness, technical difficulties limit the application of the pure transvaginal technique to highly selected cases. Technological improvements may make its use more liberal in the future. But for now, this analysis revealed that this earliest described transvaginal appendectomy technique was the least commonly preferred one relative to others subsequently described.

Another technique for pure transvaginal appendectomy was reported using the placement of a single incision laparoscopic surgery (SILS) port into the incised posterior vaginal fornix [10]. There was no abdominal trocar assistance. The authors preferred a 5 mm 30° rigid telescope and two working ports (5 mm and 12 mm) on the SILS port [10]. They divided the mesoappendix with a stapler or an energy device and the appendix was likewise divided with an endoscopic stapler. The specimens were extracted with the endoscopic bags. They reported almost half the operating time (mean 44.4 minutes) of the previously described endoscope-only pure transvaginal appendectomy. Although this new technique seemed more adaptable to daily surgical practice, the authors warned that the SILS port was inadequate as it was too short, which made placement difficult. They concluded that there was still room for innovation in the development of the technique [10].

This analysis pointed out that hybrid procedures with umbilical port assistances were more common (72%) than the pure transvaginal techniques. Hybrid techniques had some advantages over pure ones, such as safer transvaginal introduction under direct vision, transumbilical view when necessary, and two directional working in the abdominal cavity. A hybrid procedure was started with pneumoperitoneum via a Veress needle at the umbilicus and a 5 mm trocar was inserted via the umbilicus to inspect the abdominal cavity. After that a vaginal trocar (10–15 mm) was placed at the posterior fornix of the vagina. An additional working port was created in three different ways in the studies: (i) the channel of the laparoscope was used [7]; (ii) a second 5 mm trocar was inserted from the posterior fornix [15]; or (iii) a second 2.3 mm trocar was placed through the umbilicus [14]. Using a flexible endoscope instead of rigid laparoscope prolonged the operating time. No clear benefits of flexible endoscopes over the rigid scopes were seen in this systematic analysis.

Transferring the surgeons from open surgery to laparoscopic surgery provided the patients with a more comfortable postoperative course and a more rapid recovery. Another promising improvement was the single incision laparoscopic surgery. However, its benefits on postoperative pain and patient recovery were not as amazing as in the previous transfer from open to laparoscopy. A recent meta-analysis found no difference on postoperative pain and length of hospital stay between the single port and the multiport laparoscopic appendectomies [24]. Natural orifice surgery is a novel technique that can have a positive influence on postoperative pain and recovery. An important drawback of this technique may be the unfamiliarity of the access to the abdomen for surgeons who are generally familiar with abdominal incisions or transanal surgeries. A second point that may keep surgeons away from this technique is the idea that complicated surgical equipment is required. This systematic review demonstrated that, from the technical point of view, the equipment required for transvaginal appendectomy was not too distinct from the well-known existing conventional laparoscopic appendectomy equipment. There was no need for special equipment such as long trocars or flexible endoscopes.

Only two studies compared the results of transvaginal and conventional laparoscopic appendectomies [9, 10]. Despite the limited number of the patients in those studies, there was a trend towards shorter hospital stays [9, 10], quicker recovery [10], and less analgesic requirement [10] for the transvaginal groups (Table 5). On the other hand, operating time was longer at transvaginal groups. There was no difference in morbidity. As expected, cosmetic satisfaction was better for the transvaginal group [9]. Recent meta-analyses including thousands of conventional laparoscopic appendectomies demonstrated that the wound infection rate was 3.3–4% and the length of hospital stay was 1.9–2.9 days [24, 25]. When compared to those results, this systematic review demonstrated that transvaginal appendectomy can be a rational alternative to conventional laparoscopic appendectomy in selected patients. It has very low wound infection rates (zero in this study) and short hospital stays (mean 1.9 days).


Operating time (minutes)Albrecht et al. [9] (: 30 versus : 30)44.3 ± 22.133.5 ± 10.00.02
Roberts et al. [10] (: 18 versus : 22)44.4 ± 4.539.8 ± 2.6<0.01

Hospital stay (days)Albrecht et al. [9] (: 30 versus : 30)3.4 ± 1.25.0 ± 2.7<0.01
Roberts et al. [10] (: 18 versus : 22)1.1 ± 0.11.2 ± 0.1<0.01

ComplicationsAlbrecht et al. [9] (: 30 versus : 30)Urinary tract infection (1)No1.00
Roberts et al. [10] (: 18 versus : 22)Intra-abdominal abscess (1) 
Urinary retention (1)
Intestinal obstruction (1)  
Urinary retention (1)

Opioid requirement (mg)Albrecht et al. [9] (: 9 versus : 9)12.8 ± 7.014.7 ± 5.20.52
Roberts et al. [10] (: 18 versus : 22)8.7 ± 2.123.0 ± 3.4<0.01

Return to normal activity after 2 weeksAlbrecht et al. [9] (: 30 versus : 30) 70%59%0.58

Return to normal activity (days)Roberts et al. [10] (: 18 versus : 22)3.3 ± 0.49.7 ± 1.6<0.01

Return to work (days)Roberts et al. [10] (: 18 versus : 22)5.4 ± 1.110.7 ± 1.5<0.01

Cosmetic satisfactionAlbrecht et al. [9] (: 30 versus : 30)100%80%0.02
Roberts et al. [10] (: 18 versus : 22)NANANA

NA: not available.

Today, two matters can limit the widespread use of transvaginal appendectomy. First, there is not enough data of this technique for the morbidly obese patients. There is a considerable amount of obese people in the western countries and transvaginal appendectomy studies are necessary including morbid obese patients. We believe that minimal invasive surgeries like transvaginal appendectomy can have a place for the morbid obese patients in future. Secondly, the risk of delving into the cultural sensitivity of using the vagina as an access point, particularly in third world countries can be a limitation. This can be a problem even in the most promiscuous cultures where virginity still runs some amount of the population.

As a conclusion, appendectomy is one of the most common emergency visceral surgical procedures. The early results of transvaginal appendectomy in this systematic review show some promise for improved postoperative pain and patient recovery. Using hybrid techniques with rigid laparoscopes may provide an easier adaptation for surgeons to this novel appendectomy method. For now, transvaginal appendectomy looks suitable for nonmorbid obese patients (BMI < 35) and noncomplicated appendicitis. Of course, its potential advantages and disadvantages will become clearer in the future with comparative studies. More studies are also necessary on the role of transvaginal appendectomy in some subgroups like morbidly obese patients or perforated appendicitis.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.


  1. S. Sauerland, T. Jaschinski, and E. A. Neugebauer, “Laparoscopic versus open surgery for suspected appendicitis,” Cochrane Database of Systematic Reviews, vol. 10, Article ID CD001546, 2010. View at: Google Scholar
  2. S. P. Hozo, B. Djulbegovic, and I. Hozo, “Estimating the mean and variance from the median, range, and the size of a sample,” BMC Medical Research Methodology, vol. 5, article 13, 2005. View at: Publisher Site | Google Scholar
  3. J. Bernhardt, B. Gerber, H.-C. Schober, G. Kähler, and K. Ludwig, “NOTES—case report of a unidirectional flexible appendectomy,” International Journal of Colorectal Disease, vol. 23, no. 5, pp. 547–550, 2008. View at: Publisher Site | Google Scholar
  4. T. Tabutsadze and N. Kipshidze, “New trend in endoscopic surgery: transvaginal appendectomy NOTES (Natural Orifice Transluminal Endoscopic Surgery),” Georgian Medical News, no. 168, pp. 7–10, 2009. View at: Google Scholar
  5. E. J. Shin, G. A. Jeong, J. C. Jung et al., “Transvaginal endoscopic appendectomy,” Journal of the Korean Society of Coloproctology, vol. 26, no. 6, pp. 429–432, 2010. View at: Publisher Site | Google Scholar
  6. R. Zorron, C. Palanivelu, M. P. Galvão Neto et al., “International multicenter trial on clinical natural orifice surgery-Notes IMTN study: preliminary results of 362 patients,” Surgical Innovation, vol. 17, no. 2, pp. 142–158, 2010. View at: Publisher Site | Google Scholar
  7. R. C. Pérez, L. R. A. González, E. D. Reyes, J. C. D. Fernández, L. E. R. Arias, and M. O. Estrada, “The transvaginal approach in acute appendicitis,” Cirugia Espanola, vol. 89, no. 8, pp. 517–523, 2011. View at: Publisher Site | Google Scholar
  8. J. F. Noguera, A. Cuadrado, F. M. Sánchez-Margallo et al., “Emergency transvaginal hybrid natural orifice transluminal endoscopic surgery,” Endoscopy, vol. 43, no. 5, pp. 442–444, 2011. View at: Publisher Site | Google Scholar
  9. R. Albrecht, C. Bochmann, A. Süße, L. Jablonski, and U. Settmacher, “Hybrid NOS appendectomy (NA): clinical assessment of a new surgical technique,” Zentralblatt fur Chirurgie—Zeitschrift fur Allgemeine, Viszeral- und Gefasschirurgie, vol. 138, no. 4, pp. 449–455, 2013. View at: Publisher Site | Google Scholar
  10. K. E. Roberts, D. Solomon, T. Mirensky et al., “Pure transvaginal appendectomy versus traditional laparoscopic appendectomy for acute appendicitis: a prospective cohort study,” Annals of Surgery, vol. 255, no. 2, pp. 266–269, 2012. View at: Publisher Site | Google Scholar
  11. D. Solomon, R. Lentz, A. J. Duffy, R. L. Bell, and K. E. Roberts, “Female sexual function after pure transvaginal appendectomy: a cohort study,” Journal of Gastrointestinal Surgery, vol. 16, no. 1, pp. 183–187, 2012. View at: Publisher Site | Google Scholar
  12. G. R. Jacobsen, J. S. Barajas-Gamboa, A. M. Coker et al., “Transvaginal organ extraction: potential for broad clinical application,” Surgical Endoscopy, vol. 28, no. 2, pp. 484–491, 2014. View at: Publisher Site | Google Scholar
  13. A. Arezzo, C. Zornig, H. Mofid et al., “The EURO-NOTES clinical registry for natural orifice transluminal endoscopic surgery: a 2-year activity report,” Surgical Endoscopy and Other Interventional Techniques, vol. 27, no. 9, pp. 3073–3084, 2013. View at: Publisher Site | Google Scholar
  14. N. Wada, M. Tanabe, F. Kataoka, and Y. Kitagawa, “Transvaginal hybrid natural orifice translumenal endoscopic surgery appendectomy,” Nihon Geka Gakkai zasshi, vol. 114, no. 6, pp. 308–311, 2013. View at: Google Scholar
  15. H. Mofid, A. Emmermann, M. Alm, H.-A. Von Waldenfels, C. Felixmüller, and C. Zornig, “Is the transvaginal route appropriate for intra-abdominal NOTES procedures? Experience and follow-up of 222 cases,” Surgical Endoscopy and Other Interventional Techniques, vol. 27, no. 8, pp. 2807–2812, 2013. View at: Publisher Site | Google Scholar
  16. S. G. Wood, L. Panait, A. J. Duffy, R. L. Bell, and K. E. Roberts, “Complications of transvaginal natural orifice transluminal endoscopic surgery: a series of 102 patients,” Annals of Surgery, vol. 259, no. 4, pp. 744–749, 2014. View at: Publisher Site | Google Scholar
  17. S. Horgan, O. R. Meireles, G. R. Jacobsen et al., “Broad clinical utilization of NOTES: is it safe?” Surgical Endoscopy and Other Interventional Techniques, vol. 27, no. 6, pp. 1872–1880, 2013. View at: Publisher Site | Google Scholar
  18. L. Panait, S. G. Wood, R. L. Bell, A. J. Duffy, and K. E. Roberts, “Transvaginal natural orifice transluminal endoscopic surgery in the morbidly obese,” Surgical Endoscopy and Other Interventional Techniques, vol. 27, no. 7, pp. 2625–2629, 2013. View at: Publisher Site | Google Scholar
  19. S. Horgan, K. Thompson, M. Talamini et al., “Clinical experience with a multifunctional, flexible surgery system for endolumenal, single-port, and NOTES procedures,” Surgical Endoscopy, vol. 25, no. 2, pp. 586–592, 2011. View at: Publisher Site | Google Scholar
  20. K. S. Lehmann, J. P. Ritz, A. Wibmer et al., “The German registry for natural orifice translumenal endoscopic surgery: report of the first 551 patients,” Annals of Surgery, vol. 252, no. 2, pp. 263–270, 2010. View at: Publisher Site | Google Scholar
  21. S. Horgan, J. P. Cullen, M. A. Talamini et al., “Natural orifice surgery: initial clinical experience,” Surgical Endoscopy and Other Interventional Techniques, vol. 23, no. 7, pp. 1512–1518, 2009. View at: Publisher Site | Google Scholar
  22. C. Palanivelu, P. S. Rajan, M. Rangarajan, R. Parthasarathi, P. Senthilnathan, and M. Prasad, “Transvaginal endoscopic appendectomy in humans: a unique approach to NOTES—World's first report,” Surgical Endoscopy and Other Interventional Techniques, vol. 22, no. 5, pp. 1343–1347, 2008. View at: Publisher Site | Google Scholar
  23. B. Bueno, “Primer caso de apendicectomia por via vaginal,” Toko-Ginecologia Practica, vol. 8, pp. 152–154, 1949. View at: Google Scholar
  24. S. R. Markar, A. Karthikesalingam, F. di Franco, and A. M. Harris, “Systematic review and meta-analysis of single-incision versus conventional multiport appendicectomy,” British Journal of Surgery, vol. 100, no. 13, pp. 1709–1718, 2013. View at: Publisher Site | Google Scholar
  25. H. Ohtani, Y. Tamamori, Y. Arimoto, Y. Nishiguchi, K. Maeda, and K. Hirakawa, “Meta-analysis of the results of randomized controlled trials that compared laparoscopic and open surgery for acute appendicitis,” Journal of Gastrointestinal Surgery, vol. 16, no. 10, pp. 1929–1939, 2012. View at: Publisher Site | Google Scholar

Copyright © 2014 Mehmet Ali Yagci and Cuneyt Kayaalp. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles