Neurology Research International

Neurology Research International / 2012 / Article
Special Issue

Amyotrophic Lateral Sclerosis and Novel Therapeutic Strategies

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Erratum | Open Access

Volume 2012 |Article ID 853030 |

Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley, "Erratum to “Progress in Therapy Development for Amyotrophic Lateral Sclerosis”", Neurology Research International, vol. 2012, Article ID 853030, 2 pages, 2012.

Erratum to “Progress in Therapy Development for Amyotrophic Lateral Sclerosis”

Received15 Aug 2012
Accepted16 Aug 2012
Published07 Nov 2012

Please consider the following changes in Table 1.

Mendelian genes for heritable ALS (FALS)
GeneLocationHeritanceProtein Pathway or effect

ANG14q11.2DominantAngiogeninrRNA transcription
ALS22q33Recessive AlsinEndosome/membrane trafficking
C9ORF729p21.2Dominant Uncharacterized Altered C9ORF72 RNA splicing, formation of nuclear RNA foci
FIG46q21Recessive FIG4 homologEndosomal trafficking
FUS16p11.2Both Fused in sarcomaAltered RNA processing, formation of inclusion bodies
OPTN10p13BothOptineurinGolgi maintenance, membrane trafficking and exocytosis, formation of inclusion bodies
SETX9q34.12Dominant Senataxin DNA and RNA processing
SOD121q22.11Almost alwaysSuperoxide dismutase-1 Protein aggregation, possible gains of redox function, impaired axonal transport
SPG1115q21.2Recessive spatacsinImpaired axonal transport
TARDPB1p36.22Dominant TAR DNA bindingRNA processing, formation of protein inclusion bodies
UBQLN2Xp11.231 dominantX-linked Ubiquilin-2Proteosomal protein degradation, inclusion body formation
VAPB20q13.32DominantVesicle-associated membrane protein VAMPVesicle trafficking
VCP9p13.3Dominant Valosin-containing proteinProteosomal degradation, endosomal trafficking, vesicle sorting
PFN117p13.3Dominant Profilin-1Actin polymerization regulator

Susceptibility loci for sporadic ALS (SALS)
GeneLocationPolymorphismProteinOR (95% CI)

GWA_9p21.29p21.2rs2814707Unknown 1.25 (1.19–1.32)
UNC13A19p13.1rs12608932 homologUnc-13 vesicle protein1.18 (1.13–1.24)
ATXN212q24.12Poly-QAtaxin-2 N.a.

Copyright © 2012 Kalina Venkova-Hristova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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