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Oxidative Medicine and Cellular Longevity
Volume 2019, Article ID 5461617, 8 pages
https://doi.org/10.1155/2019/5461617
Research Article

Early Kidney Damage Markers after Deferasirox Treatment in Patients with Thalassemia Major: A Case-Control Study

1Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
2Department of Immunology and Microbiology, Guilan University of Medical Sciences, Rasht, Iran
3Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
4Council for Agricultural Research and Economics, Research Centre for Food and Nutrition (CREA-AN), Via Ardeatina 546, 00178 Rome, Italy

Correspondence should be addressed to Bahram Darbandi; moc.liamg@54idnabrad and Wesam Kooti; moc.liamg@itookmasew

Received 29 August 2018; Accepted 24 February 2019; Published 21 April 2019

Academic Editor: Nadja Schroder

Copyright © 2019 Hamidreza Badeli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The life of patients with β-thalassemia major depends on blood transfusion. Regular blood transfusion leads to hemosiderosis in their main organs. The aim of this study was to compare the effects of deferasirox and deferoxamine on renal damage in patients with β-thalassemia major. Method. The present case-control study was conducted on 60 individuals who were referred to the 17th Shahrivar Tertiary Referral Hospital in Guilan province, Iran. In this study, patients with β-thalassemia major who used deferasirox () and patients who used deferoxamine () were evaluated. The control group () was selected from healthy individuals. Serum creatinine (CREA), blood urea nitrogen (BUN), and Cystatin C were measured from blood samples. Furthermore, urinary (U.) neutrophil gelatinase-associated lipocalin (NGAL), albumin (Alb), interleukin- (IL-) 18, and Kidney Injury Molecule-1 (KIM-1) were measured by the ELISA method and normalized for U. creatinine (CREA). Results. U. NGAL, U. IL-18, and BUN biomarkers in the deferasirox group were significantly higher than those in the control group (). U. NGAL/CREA and U. KIM-1/CREA ratios increased in both the deferoxamine and deferasirox groups compared to the control group (). U. Alb was significantly higher in patients treated with deferoxamine than in healthy participants (). Conclusion. The findings of this study indicate that after taking deferasirox, there was renal damage and an increase in inflammatory factors. Also, minor renal impairment was observed after deferoxamine administration, but it was not confirmed at the molecular level (U. NGAL and KIM-1). Therefore, it seems that patients who are taking these two drugs should be monitored carefully.