Oxidative Medicine and Cellular Longevity

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics


Publishing date
01 Nov 2021
Status
Closed
Submission deadline
18 Jun 2021

Lead Editor

1Third Hospital of Hebei Medical University, Shijiazhuang, China

2University of Sydney, Sydney, Australia

3University of New South Wales, Sydney, Australia

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress in Intervertebral Disc Degeneration and its Related Therapeutics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Intervertebral disc (IVD) degeneration, an important cause of discogenic lower back pain (LBP), has traditionally been thought to be an age-related process of the disc tissue caused by decreased proteoglycan content, eventually leading to decreased intervertebral height, endplate sclerosis and osteophyte formation. IVD degeneration can cause a variety of spinal diseases including lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy. Over the past decades, IVD degeneration-related diseases have been causing an enormous socio-economic burden and leading to low quality of life.

The process of IVD degeneration is complicated. Although the mechanism of IVD degeneration is not fully understood, altered mechanical loading, degradation of the extracellular matrix (ECM), increased secretion of inflammatory factors, excessive senescence, and aberrant apoptosis of IVD cells have proved to play important roles in the progression of IVD degeneration. Previous studies in humans and experimental animal models have well documented that oxidative stress and damage can result in excessive apoptosis and autophagy of IVD cells and further lead to IVD degeneration. However, the specific signalling pathways underlying the pathogenesis still remain elusive, making it very difficult to find potential therapeutics targeting that unclear mechanism.

This Special Issue will focus on the specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing, as well as potential therapeutic molecules to attenuate the progression of IVD degeneration. In particular, the effect of steroids (e.g., estrogen) on delaying IVD degeneration and ageing, in terms of both in vivo and in vitro investigations. Contributions with original research are extremely welcome if that would provide new insights for understanding the pathophysiological mechanism of oxidative damage-induced IVD degeneration and/or novel discovery of its diagnostics and therapeutics. Review articles that help better understand the existing knowledge regarding the role of oxidative stress and related therapeutics are also encouraged.

Potential topics include but are not limited to the following:

  • Oxidative stress in IVD degeneration and aging related diseases, including LBP, lumbar disc herniation, lumbar spondylolisthesis, spinal stenosis, scoliosis, and cervical spondylopathy
  • Specific molecular pathways underlying oxidative stress-induced IVD degeneration and ageing
  • Potential therapeutic molecules to attenuate the progression of IVD degeneration
  • Novel or potential diagnostics and prognosis for IVD degeneration and ageing related diseases
  • Original research on potential medicinal plants are also welcome if the mechanism or molecular targets are also elucidated in treating IVD degeneration-related diseases
  • Bioinformatical analysis of the underlying mechanisms related to oxidative stress-induced IVD degenerative diseases, including but not limited to differential gene expression, functional and pathway enrichment analyses, and module analyses for protein-protein interaction (PPI) network
  • Bioengineering therapeutics for oxidative stress-induced IVD degenerative diseases
  • Meta-analysis of randomized controlled trials or primary clinical data used to evaluate the efficacy, or otherwise, of novel or potential therapeutics for IVD degeneration-related diseases

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 5608133
  • - Research Article

Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model

Bao-Liang Li | Xizhe Liu | ... | Shaoyu Liu
  • Special Issue
  • - Volume 2021
  • - Article ID 5579736
  • - Research Article

Glycine-Serine-Threonine Metabolic Axis Delays Intervertebral Disc Degeneration through Antioxidant Effects: An Imaging and Metabonomics Study

Xiaolin Wu | Chang Liu | ... | Hongfei Xiang
  • Special Issue
  • - Volume 2021
  • - Article ID 9965737
  • - Research Article

TRPV1 Channel Activated by the PGE2/EP4 Pathway Mediates Spinal Hypersensitivity in a Mouse Model of Vertebral Endplate Degeneration

Sijing Liu | Qiong Wang | ... | Chuan Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 3225439
  • - Research Article

Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction

Kaiqiang Sun | Xiaofei Sun | ... | Jiangang Shi
  • Special Issue
  • - Volume 2021
  • - Article ID 3843145
  • - Research Article

FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells

Rongjin Luo | Shuai Li | ... | Cao Yang
  • Special Issue
  • - Volume 2021
  • - Article ID 6389568
  • - Research Article

HIF-1α-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP

Xiaogang Bao | Zhenhua Wang | ... | Guohua Xu
  • Special Issue
  • - Volume 2021
  • - Article ID 6192498
  • - Research Article

Deficiency of MIF Accentuates Overloaded Compression-Induced Nucleus Pulposus Cell Oxidative Damage via Depressing Mitophagy

Yiyang Wang | Yanzhu Hu | ... | Qiang Zhou
  • Special Issue
  • - Volume 2021
  • - Article ID 5584447
  • - Research Article

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo

Zhiwei Liao | Suyun Li | ... | Cao Yang
  • Special Issue
  • - Volume 2021
  • - Article ID 5542241
  • - Research Article

Exosomal MATN3 of Urine-Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF-β

Zhu Guo | WeiLiang Su | ... | HongFei Xiang
  • Special Issue
  • - Volume 2021
  • - Article ID 5556122
  • - Research Article

Sodium Tanshinone IIA Sulfonate Ameliorates Injury-Induced Oxidative Stress and Intervertebral Disc Degeneration in Rats by Inhibiting p38 MAPK Signaling Pathway

Shouqian Dai | Xiu Shi | ... | Huilin Yang
Oxidative Medicine and Cellular Longevity
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CiteScore7.900
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