Development and Physicochemical Characterization of Desonide-Loaded Nanocapsule Suspensions

Table 5

Release constants, correlation coefficients, and MSC obtained by fitting the release profiles of desonide using dialysis sac, according to the monoexponential and biexponential equations.

Equation	D-LNC	D-NC-S100	D-NC-L100	Free-desonide
Monoexponential
(h^−1)	0.47 ± 0.09	0.53 ± 0.17	0.76 ± 0.19	0.40 ± 0.07
(h)	1.51 ± 0.28	1.38 ± 0.21	0.98 ± 0.35	1.77 ± 0.29
MSC	4.52 ± 0.40	2.93 ± 0.39	3.95 ± 0.26	4.21 ± 0.76
	0.997 ± 0.002	0.984 ± 0.004	0.995 ± 0.003	0.994 ± 0.007
Biexponential
	0.40 ± 0.10	0.16 ± 0.01	0.12 ± 0.01	0.14 ± 0.03
(h^−1)	0.34 ± 0.08	1.12 ± 0.26	1.72 ± 0.07	1.11 ± 0.55
	0.58 ± 0.07	0.83 ± 0.03	0.87 ± 0.01	0.84 ± 0.04
(h^−1)	0.27 ± 0.05	0.006 ± 0.001	0.013 ± 0.004	0.017 ± 0.003
MSC	4.21 ± 0.36	5.28 ± 0.35	4.90 ± 0.36	5.14 ± 0.22
	0.997 ± 0.002	0.998 ± 0.001	0.998 ± 0.001	0.994 ± 0.004

Experiments were conducted with .