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BioMed Research International
Volume 2013, Article ID 126189, 12 pages
Research Article

IL-6 Production by Dendritic Cells Is Dispensable for CD8+ Memory T-Cell Generation

1Maisonneuve-Rosemont Hospital Research Center, University of Montreal, 5415 Boulevard de l’Assomption, Montréal, QC, Canada H1T 2M4
2Department of Microbiology and Immunology, University of Montreal, Montréal, QC, Canada H3C 3J7
3Department of Medicine, University of Montreal, Montréal, QC, Canada H3C 3J7

Received 18 May 2012; Accepted 19 June 2012

Academic Editor: Zhengguo Xiao

Copyright © 2013 Jean-François Daudelin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure S1: Shows the similar phenotype of CD8+ effectors generated after CD40-B cell immunization with or without IL-6 supplementation.

Supplementary Figure S2: Shows that wild-type and IL-6-deficient DCs have the same phenotypic characteristics has shown by their similar expression of CD11c, MHC class I and II molecules, CD86, CD80 and Kb-OVA.

Supplementary Figure S3: shows that CD8+ effector T cells obtained following immunization with wild-type or IL-6-deficient DCs express similar level of CD44, CD127, 1B11, CD62L, CXCR3 and KLRG1.

  1. Supplementary Figure S1
  2. Supplementary Figure S2
  3. Supplementary Figure S3