BioMed Research International

Aberrant Gene Regulation in Obstetric, Gynecologic, and Reproductive Diseases


Status
Published

1Mercer University School of Medicine, Macon, USA

2Mayo Clinic and Mayo Medical School, Rochester, USA

3Zhejiang University School of Medicine, Zhejiang, China

4Weifang Medical University, Shandong, China


Aberrant Gene Regulation in Obstetric, Gynecologic, and Reproductive Diseases

Description

Aberrant gene expression is an important pathological mechanism that is subject to tight control at multiple steps, including transcription, mRNA splicing, and translation. Genetic mutations in germline or somatic cells lead to expression alteration of the cognate or downstream genes. Nutrition and environmental factors may affect human health via modulation of gene expression; one major function of epigenetic pathways is the transcriptional silencing/activation. For this reason, transcriptional factors are used as biomarkers for diagnosis and/or risk evaluations. Since gene regulation is sensitive to preventive or therapeutic interference and is directly related to the outcomes of management procedures, understanding of gene regulation is often required for the development of new treatment modalities.

This special issue will focus on gene regulation in obstetric, gynecologic, and reproductive diseases. We invite investigators to contribute with original and review articles that will enrich our knowledge on gene regulation alterations that are relevant to the mechanisms, diagnosis, and treatment of infertility and abnormality of reproductive endocrinology, preeclampsia, and gynecologic cancers, although an excellent manuscript with a clear focus on gene regulation mechanism in other systems will also be considered. Priority for publication is given to new findings applying novel approach, models, or study subjects.

Potential topics include, but are not limited to:

  • Gene regulation and its involvement in the pathogenesis of obstetric, gynecologic, and reproductive diseases
  • Epigenetic alterations, including those in DNA methylation, chromatin remodeling, and noncoding RNA
  • Gene regulation by endogenous and exogenous hormones and nutrition, life style, and environmental factors in reproductive system
  • Transcription regulators and epigenetic factors as biomarkers or therapeutic targets for the management of obstetric, gynecologic, and reproductive diseases

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 187691
  • - Editorial

Aberrant Gene Regulation in Obstetric, Gynecologic, and Reproductive Diseases

Shi-Wen Jiang | Brian Brost | ... | Chun-E Ren
  • Special Issue
  • - Volume 2015
  • - Article ID 760698
  • - Research Article

Profiling of Selected MicroRNAs in Proliferative Eutopic Endometrium of Women with Ovarian Endometriosis

P. Laudanski | R. Charkiewicz | ... | J. Niklinski
  • Special Issue
  • - Volume 2015
  • - Article ID 854056
  • - Review Article

Participation of WNT and β-Catenin in Physiological and Pathological Endometrial Changes: Association with Angiogenesis

Jolanta Kiewisz | Tomasz Wasniewski | Zbigniew Kmiec
  • Special Issue
  • - Volume 2015
  • - Article ID 598386
  • - Research Article

Lysophosphatidic Acid Inhibits Apoptosis Induced by Cisplatin in Cervical Cancer Cells

Yanxia Sui | Ya Yang | ... | Juan Ren
  • Special Issue
  • - Volume 2015
  • - Article ID 323246
  • - Research Article

Effects of Mitochondrial Uncoupling Protein 2 Inhibition by Genipin in Human Cumulus Cells

Hongshan Ge | Fan Zhang | ... | Jeiqiang Lv
  • Special Issue
  • - Volume 2015
  • - Article ID 925691
  • - Research Article

Paracrine Regulation of Steroidogenesis in Theca Cells by Granulosa Cells Derived from Mouse Preantral Follicles

Xiaoqiang Liu | Pengyun Qiao | ... | Chune Ren
  • Special Issue
  • - Volume 2015
  • - Article ID 416929
  • - Clinical Study

Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women

Mansur Rahnama | Izabela Jastrzębska-Jamrogiewicz | ... | Grzegorz Trybek
  • Special Issue
  • - Volume 2015
  • - Article ID 652017
  • - Research Article

BRCA1 185delAG Mutation Enhances Interleukin-1β Expression in Ovarian Surface Epithelial Cells

Kamisha T. Woolery | Mai Mohamed | ... | Patricia A. Kruk
  • Special Issue
  • - Volume 2015
  • - Article ID 420891
  • - Review Article

EMT-Inducing Molecular Factors in Gynecological Cancers

Loredana Campo | Catherine Zhang | Eun-Kyoung Breuer
  • Special Issue
  • - Volume 2015
  • - Article ID 201629
  • - Research Article

Decorin-Mediated Inhibition of Human Trophoblast Cells Proliferation, Migration, and Invasion and Promotion of Apoptosis In Vitro

Yanfen Zou | Xiang Yu | ... | Lizhou Sun
BioMed Research International
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Acceptance rate31%
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