Smooth Muscle-Specific BCL6+/− Knockout Abrogates Sex Bias in Chronic Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

Figure 4

Abrogation of the male sex bias in chronic hypoxia-induced PAH in SMC:BCL6+/− mice: right ventricular systolic pressures (RVSP). Groups of male and female Wt and SMC:BCL6+/− knockout mice (–7 mice per group as indicated) were subjected to hypobaric hypoxia (10% v/v oxygen) or kept in room air for 4 weeks. At the end of the experiment, Millar catheterization was used to measure the RVSP (Figure 4 and [19]), the PA wall thickness (see Figure 5), muscularization of PA vessels in lung sections (Figure 6(a)), and right ventricular hypertrophy (the ratio of RV/LV + S wet weights) (Figure 6(b)). (a) Mean RVSP is shown in each group (mean ± SE). (b) The RVSP for each individual mouse is shown. by ANOVA; NS, not significant.

(a)

(b)