Heung-Chin Cheng

University of Melbourne, Australia

Heung-Chin Cheng's research interest has been focusing on the regulation and function of disease-related protein kinases and phosphatases since he was a graduate student in Dr. Donal Walsh's laboratory in the University of California at Davis. In his PhD studies, he unveiled how cAMP-dependent protein kinase is inhibited by its endogenous inhibitor protein and how the kinase recognises protein substrates. After a brief stay as a postdoctoral fellow in the late Dr. Choh Hao Li's laboratory in the UCSF where he studied the structure and function of beta-endorphin and the chemistry of peptide segment coupling, he moved to joined Dr. Jerry Wang's laboratory in the University of Calgary to further his postdoctoral training. In Calgary, he started his research in the Src-family tyrosine kinases and protein phosphatases. Since he joined University of Melbourne as a faculty member in 1993, he expanded his interest to investigation of the roles of protein kinases and phosphatases in pathogenesis and progression of cancer and neurodegenerative diseases. The research projects ongoing in his laboratory include: 1. The structure and function of CSK-homologous kinase (Ctk) 2. The role of Src-family kinases in excitotoxic neuronal death and cancer 3. The structure and function of the Parkinson’s disease-related protein kinases PINK1 and LRRK2 4. Regulation and function of the protein and phospholipid phosphatase PTEN 5. Development of chemosensor peptide substrates of protein kinases

Biography Updated on 23 January 2012

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