David Allen Boothman

University of Texas Southwestern Medical Center at Dallas, USA


David Allen Boothman received his Ph.D. degree in microbiology, immunology, and biochemistry from the University of Miami, Coral Gables, FL, USA, after a three-year postdoctoral fellowship (with Dr. Arthur B. Pardee) at the Cell Growth and Regulation Division, the Dana-Farber Cancer Institute, Boston, MA, USA. Boothman is currently the Robert and Virginia Payne’s Professor of oncology. He is a Professor of pharmacology and radiation oncology and the Associate Director of translational research at the Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA. Boothman has been an Assistant Professor at the University of Michigan, Ann Arbor, MI, USA; Associate Professor at the University of Wisconsin-Madison, Madison, WI, USA; and a Full Professor at the Case Western Reserve University, Cleveland, OH, USA. Boothman has been a Faculty Member of a cancer center since 1989. From 1999 to 2005, he was a Faculty Member at the Case Comprehensive Cancer Center, Cleveland, OH, USA, where he was the Codirector of the ET Program, and, from 2000 to 2005, he was the Associate Director for basic research. In 2005, Boothman moved to the UT Southwestern Medical Center, Dallas, TX, USA, to colead (with Dr. Gao) the Cell Stress and Cancer Nanomedicine Division, the Southwestern Clinical Center (SCC), Dallas, TX, USA, and aid in the development of the infrastructure needed for standardized phase I/II pharmacodynamic (PD) laboratory correlates. The research in his laboratory is focused on the following three areas: DNA repair and links between RNA transcription termination and nonhomologous end joining, PARP 1 hyperactivation-induced programmed cell death and DNA repair inhibition, and TFGβ1-induced gene expression and metabolic reprogramming during epithelial-to-mesenchymal transition (EMT) occurring during metastasis.

Biography Updated on 8 December 2013

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