Ira H. Pastan

National Cancer Institute, USA

Ira Pastan was educated at the Boston Public Latin School, Tufts College, and Tufts Medical School. He did his residency at the Yale School of Medicine (1957-1959) and came to NIH in 1959. 1970, he was appointed as the Chief of the Laboratory of Molecular Biology. He won many prizes, awards, and honors as well as other special scientific recognition. He holds several memberships in many societies. His research activities include developing a new therapy for cancer by making fusion proteins composed of the Fv portion of antibodies directed at receptor proteins on cancer cells fused to a genetically modified form of a powerful bacterial toxin, Pseudomonas exotoxin A. Because immunotoxins induce neutralizing antibodies in patients with normal immune systems limiting their use, he uses protein engineering to make less immunogenic immunotoxins.

Biography Updated on 29 November 2011

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